Evidence map›Paper›PMID 42211845›Full record

ReviewFrontiers in microbiology2026

Viral vectors for antimicrobial peptide expression: a new path for crop protection.

M Basaloco, A Albuquerque, J A Ribeiro, M Patanita, F Santos, T Monteiro, M D Campos, C Varanda, M R Félix

Abstract readReview
In one paragraph

Review in Frontiers in microbiology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

M BasalocoMED Mediterranean Institute for Agriculture, Environment and Development & CHANGE Global-Change and Sustainability Institute, Institute for Advanced Studies and Research, Universidade de Évora, Évora, Portugal.
A AlbuquerqueMED Mediterranean Institute for Agriculture, Environment and Development & CHANGE Global-Change and Sustainability Institute, Institute for Advanced Studies and Research, Universidade de Évora, Évora, Portugal.
J A RibeiroMED Mediterranean Institute for Agriculture, Environment and Development & CHANGE Global-Change and Sustainability Institute, Institute for Advanced Studies and Research, Universidade de Évora, Évora, Portugal.
M PatanitaMED Mediterranean Institute for Agriculture, Environment and Development & CHANGE Global-Change and Sustainability Institute, Institute for Advanced Studies and Research, Universidade de Évora, Évora, Portugal.
F SantosDepartamento de Fitotecnia, Escola de Ciências e Tecnologia, MED Mediterranean Institute for Agriculture, Environment and Development & CHANGE-Global Change and Sustainability Institute, Universidade de Évora, Évora, Portugal.
T MonteiroMED Mediterranean Institute for Agriculture, Environment and Development & CHANGE Global-Change and Sustainability Institute, Institute for Advanced Studies and Research, Universidade de Évora, Évora, Portugal.
M D CamposDepartamento de Fitotecnia, Escola de Ciências e Tecnologia, MED Mediterranean Institute for Agriculture, Environment and Development & CHANGE-Global Change and Sustainability Institute, Universidade de Évora, Évora, Portugal.
C VarandaMED Mediterranean Institute for Agriculture, Environment and Development & CHANGE Global-Change and Sustainability Institute, Institute for Advanced Studies and Research, Universidade de Évora, Évora, Portugal.
M R FélixDepartamento de Fitotecnia, Escola de Ciências e Tecnologia, MED Mediterranean Institute for Agriculture, Environment and Development & CHANGE-Global Change and Sustainability Institute, Universidade de Évora, Évora, Portugal.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Antimicrobial peptides (AMPs) are key components of plant innate immunity, offering broad spectrum protection against pathogens and represent promising alternatives to chemical pesticides for sustainable crop protection. Despite their broad range antimicrobial activity and low potential for resistance development, the deployment of AMPs in agriculture has been severely limited by instability, poor bioavailability and the lack of efficient, field-compatible delivery strategies. Harnessing viral vectors as platforms for AMP expression in plants represents a powerful strategy to enhance plant innate immunity. This review provides an overview of the potential of viral vectors for transient gene expression, functional genomics and genome editing. We discuss the design, construction and delivery of viral vectors, as well as the main challenges associated with AMP expression, including cytotoxicity and stability. Finally, inspired by adeno-associated virus (AAV) mediated AMP delivery strategies in mammals, we propose a vaccine-like strategy for plant protection, in which viral vectors enable endogenous AMP production Although plants lack adaptive immunity, virus-mediated AMP expression may function as a biochemical analog, reinforcing basal defence layers and enhancing tolerance to pathogen infection. By integrating viral biotechnology with plant defence mechanisms, this approach could redefine the future of sustainable agriculture.

Indexed as

antimicrobial activitybiotechnologyplant protectionsustainable agriculturetransient expression systems

Identifiers

PMID42211845
PMCPMC13212320

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.