Evidence map›Paper›PMID 42211834›Full record

ArticleFrontiers in microbiology2026

High-zinc diets accelerate molting and recovery by remodeling the cecal microbiome in laying hens.

Ling Chang, Fang Peng, Yue Zuo, Shihao Yang, Kun Xie, Zehe Song, Xi He, Yuguang Chen

Abstract read
In one paragraph

Article in Frontiers in microbiology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Ling ChangCollege of Animal Science and Technology, Hunan Agricultural University, Changsha, Hunan, China.
Fang PengCollege of Animal Science and Technology, Hunan Agricultural University, Changsha, Hunan, China.
Yue ZuoBeijing No.80 High School, Beijing, China.
Shihao YangCollege of Animal Science and Technology, Hunan Agricultural University, Changsha, Hunan, China.
Kun XieCollege of Animal Science and Technology, Hunan Agricultural University, Changsha, Hunan, China.
Zehe SongCollege of Animal Science and Technology, Hunan Agricultural University, Changsha, Hunan, China.
Xi HeCollege of Animal Science and Technology, Hunan Agricultural University, Changsha, Hunan, China.
Yuguang ChenCollege of Animal Science and Technology, Hunan Agricultural University, Changsha, Hunan, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Introduction: Conventional fasting molting can restore laying performance but imposes substantial physiological stress and welfare concerns. High-zinc diets (2% ZnO) have been proposed as a less stressful alternative, but their mechanisms remain unclear. Methods: This study compared fasting-induced molting with zinc oxide supplementation in 384 Lohmann Pink hens (65 wk). Serum, cecal contents, and ovaries were sampled across six stages from pre-molt to post-molt recovery. Results: ZnO accelerated cessation of lay (5.75 vs. 8.87 d) and earlier recovery to 50% production (15.25 vs. 16.62 d) with lower weight loss (25% vs. 30%). Multi-omics revealed that high-zinc feeding enriched beneficial microbes (e.g., Discussion/conclusion: These findings support that a high-zinc-associated microbial-metabolic profile mitigates stress, accelerates ovarian reset, and shortens the time to restore production.

Indexed as

amino acid metabolismgut microbiotagut-ovary axishigh-zincmolting

Identifiers

PMID42211834
PMCPMC13212241

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.