ArticleRSC advances2026
Generic microfluidic platform for digital droplet-based bioassays.
Julia Sophie Böke, Cornelia Reuter, Mark Kielpinski, Anett Reichert, Iris Prinz, Daniel Horner, Adrian Prinz, Fritz Bichler, Rudolf Aichinger, Anton Rettenbacher and 5 more
Abstract read
In one paragraphArticle in RSC advances, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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0citing papers in PubMed
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What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
2 · The registryThe trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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3 · Its place in the literatureWho cites it
0 citing papers in PubMed.
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4 · The recordCorrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
5 · Who and what moneyAuthors and funding
15 authors.
Julia Sophie BökeLeibniz Institute of Photonic Technology, Member of the Research Alliance "Leibniz Health Technologies", The Leibniz Centre for Photonics in Infection Research (LPI) Albert-Einstein-Straße 9 07745 Jena Germany cornelia.reuter@leibniz-ipht.de thomas.henkel@leibniz-ipht.de.ORCID https://orcid.org/0000-0002-8901-8543 Cornelia ReuterLeibniz Institute of Photonic Technology, Member of the Research Alliance "Leibniz Health Technologies", The Leibniz Centre for Photonics in Infection Research (LPI) Albert-Einstein-Straße 9 07745 Jena Germany cornelia.reuter@leibniz-ipht.de thomas.henkel@leibniz-ipht.de.ORCID https://orcid.org/0000-0002-9060-3344 Mark KielpinskiLeibniz Institute of Photonic Technology, Member of the Research Alliance "Leibniz Health Technologies", The Leibniz Centre for Photonics in Infection Research (LPI) Albert-Einstein-Straße 9 07745 Jena Germany cornelia.reuter@leibniz-ipht.de thomas.henkel@leibniz-ipht.de.
Anett ReichertLeibniz Institute of Photonic Technology, Member of the Research Alliance "Leibniz Health Technologies", The Leibniz Centre for Photonics in Infection Research (LPI) Albert-Einstein-Straße 9 07745 Jena Germany cornelia.reuter@leibniz-ipht.de thomas.henkel@leibniz-ipht.de.
Iris PrinzSTRATEC Consumables GmbH Sonystr. 20, 5081 Anif Salzburg Austria.
Daniel HornerSTRATEC Consumables GmbH Sonystr. 20, 5081 Anif Salzburg Austria.
Adrian PrinzSTRATEC Consumables GmbH Sonystr. 20, 5081 Anif Salzburg Austria.
Fritz BichlerSTRATEC Consumables GmbH Sonystr. 20, 5081 Anif Salzburg Austria.
Rudolf AichingerSTRATEC Consumables GmbH Sonystr. 20, 5081 Anif Salzburg Austria.
Anton RettenbacherSTRATEC Consumables GmbH Sonystr. 20, 5081 Anif Salzburg Austria.
Georg BauerSTRATEC Consumables GmbH Sonystr. 20, 5081 Anif Salzburg Austria.
Maria BauerSTRATEC Consumables GmbH Sonystr. 20, 5081 Anif Salzburg Austria.
Susanne PahlowLeibniz Institute of Photonic Technology, Member of the Research Alliance "Leibniz Health Technologies", The Leibniz Centre for Photonics in Infection Research (LPI) Albert-Einstein-Straße 9 07745 Jena Germany cornelia.reuter@leibniz-ipht.de thomas.henkel@leibniz-ipht.de.ORCID https://orcid.org/0000-0002-2421-4519 Karina WeberLeibniz Institute of Photonic Technology, Member of the Research Alliance "Leibniz Health Technologies", The Leibniz Centre for Photonics in Infection Research (LPI) Albert-Einstein-Straße 9 07745 Jena Germany cornelia.reuter@leibniz-ipht.de thomas.henkel@leibniz-ipht.de.
Thomas HenkelLeibniz Institute of Photonic Technology, Member of the Research Alliance "Leibniz Health Technologies", The Leibniz Centre for Photonics in Infection Research (LPI) Albert-Einstein-Straße 9 07745 Jena Germany cornelia.reuter@leibniz-ipht.de thomas.henkel@leibniz-ipht.de.ORCID https://orcid.org/0000-0003-2896-500X Funding
No grant is acknowledged in the PubMed record.
6 · The paper itselfAbstract
Digital droplet-based bioassays (ddAssays) have been applied in numerous fields, though many existing microfluidic platforms are tailored to specific assay classes and require complex workflows involving multiple processing steps. Here, we present a fully integrated microfluidic platform for generic digital bioassays that combines droplet generation and storage for on-chip incubation and optical readout on a single disposable device. This microfluidic platform enables the parallel execution of test and control experiments, each using more than 200 000 monodisperse droplets of 35 pL. CFD simulations of the step emulsification unit, together with experimental characterization, confirm the predicted device performance. The device is prepared by variothermal compression molding. A dual-layer photoresist strategy was used to create the master for replicating the channel systems with two different channel heights and step transitions between them. The core functionality and the applicability of various optical modalities for image-based readout are demonstrated by exemplary biochemical and microbial growth reporter assays. The platform is compatible with automated image-based analysis for high-throughput digital assay readout.
Identifiers
PMID42211792
PMCPMC13213550
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LicenceCC BY-NC
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