Evidence map›Paper›PMID 42211775›Full record

ArticleEuropean heart journal. Digital health2026

A digital health program enhances walking capacity and health status in symptomatic peripheral artery disease.

Vishal Amlani, Bartosz Dobies, Carl-Magnus Wahlgren, Manne Andersson, Birgitta Sigvant, Anders Gottsäter, Moncef Zarrouk, Olga Nilsson, Hallur Hallsson, Linda Karlsdottir and 3 more

Abstract read
In one paragraph

Article in European heart journal. Digital health, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Vishal AmlaniInstitute of Medicine, Department of Molecular and Clinical Medicine, University of Gothenburg, Sweden.ORCID https://orcid.org/0009-0002-1828-6580
Bartosz DobiesSidekick Health Digital Therapeutics®, Kopavogur, Iceland.ORCID https://orcid.org/0009-0000-8851-3692
Carl-Magnus WahlgrenDepartment of Vascular Surgery, Karolinska University Hospital and Karolinska Institutet, Stockholm, Sweden.
Manne AnderssonDepartment of Biomedical and Clinical Sciences, Faculty of Health Sciences, Linköping University, Linköping, Sweden.
Birgitta SigvantRegion Värmland, Centre for Clinical Research and Education, Department of Surgical Sciences, Uppsala University, Uppsala, Sweden.ORCID https://orcid.org/0000-0002-8186-135X
Anders GottsäterLund University, Department of Medicine, Skåne University Hospital, Malmö, Sweden.ORCID https://orcid.org/0000-0003-0865-0000
Moncef ZarroukVascular Centre, Department of Cardiothoracic and Vascular Surgery, Skåne University Hospital, Malmö, Sweden.
Olga NilssonDepartment of Vascular Surgery, Karolinska University Hospital and Karolinska Institutet, Stockholm, Sweden.ORCID https://orcid.org/0000-0002-7670-1677
Hallur HallssonSidekick Health Digital Therapeutics®, Kopavogur, Iceland.
Linda KarlsdottirSidekick Health Digital Therapeutics®, Kopavogur, Iceland.
Sæmundur OddssonSidekick Health Digital Therapeutics®, Kopavogur, Iceland.
Tryggvi ThorgeirssonSidekick Health Digital Therapeutics®, Kopavogur, Iceland.ORCID https://orcid.org/0000-0003-4963-6424
Joakim NordanstigInstitute of Medicine, Department of Molecular and Clinical Medicine, University of Gothenburg, Sweden.ORCID https://orcid.org/0000-0002-2670-2268

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Aims: Intermittent claudication (IC) is the most common manifestation of peripheral artery disease (PAD), an atherosclerotic condition associated with high cardiovascular morbidity and mortality. Management targets cardiovascular risk reduction and limb function, but effective non-invasive treatments for limb symptoms remain limited. The aim of this prospective, multicentre randomized controlled trial was to evaluate whether a 12-week multimodal smartphone-based digital health programme improves walking capacity and symptoms in patients with IC. Methods and results: The IPAD trial compared standard care alone with standard care plus a 12-week digital health intervention focused on lifestyle modification and physical activity, incorporating behavioural change techniques and gamification. The primary observer-blinded endpoint was maximum walking distance (MWD) during a 6-min walk test (6MWT), contextualized against minimal clinically important difference thresholds. Secondary endpoints included pain-free 6MWT distance and health-related quality of life (HRQoL). Over 21 months, 155 patients were randomized 1:1. Mean (SD) age was 71.8 (7.6) years. Compared with controls, the intervention group showed greater improvement in MWD (+21.44 m; 95% confidence interval [CI] 6.00-36.87; Conclusion: The digital health programme resulted in a clinically meaningful improvement in walking capacity in PAD patients with IC.

Indexed as

Digital healthIntermittent claudicationPeripheral artery disease

Identifiers

PMID42211775
PMCPMC13215472

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.