Evidence map›Paper›PMID 42211753›Full record

ArticleFood chemistry. Molecular sciences2026

Heat stress induces ferroptosis in intramuscular preadipocytes of Hu sheep via activation of the TNF-α/NF-κB/GPX4 signaling axis.

Shaoqiang Wu, Yirong Wei, Zhuangzhuang Han, Haien He, Jun Lu, Yishan Liang, Lianghuan Tang, Jianwei Zou, Yu Zhang, Yanna Huang and 1 more

Abstract read
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In one paragraph

Article in Food chemistry. Molecular sciences, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Shaoqiang WuCollege of Animal Science and Technology, Guangxi University, Nanning 530004, Guangxi, China.
Yirong WeiCollege of Animal Science and Technology, Guangxi University, Nanning 530004, Guangxi, China.
Zhuangzhuang HanCollege of Animal Science and Technology, Guangxi University, Nanning 530004, Guangxi, China.
Haien HeCollege of Animal Science and Technology, Guangxi University, Nanning 530004, Guangxi, China.
Jun LuCollege of Animal Science and Technology, Guangxi University, Nanning 530004, Guangxi, China.
Yishan LiangCollege of Animal Science and Technology, Guangxi University, Nanning 530004, Guangxi, China.
Lianghuan TangCollege of Animal Science and Technology, Guangxi University, Nanning 530004, Guangxi, China.
Jianwei ZouCollege of Animal Science and Technology, Guangxi University, Nanning 530004, Guangxi, China.
Yu ZhangCollege of Animal Science and Technology, Guangxi University, Nanning 530004, Guangxi, China.
Yanna HuangCollege of Animal Science and Technology, Guangxi University, Nanning 530004, Guangxi, China.
Qinyang JiangCollege of Animal Science and Technology, Guangxi University, Nanning 530004, Guangxi, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Heat stress (HS) induced by high ambient temperatures markedly disrupts metabolic homeostasis and meat quality development in ruminants, with reduced intramuscular fat (IMF) deposition is considered a major contributor to meat quality deterioration. However, the roles and underlying mechanisms by which inflammatory responses and ferroptosis in the regulation of IMF deposition in Hu sheep under HS conditions remain unclear. This study showed that HS markedly increased the production of pro-inflammatory cytokines, such as TNF-α, IL-6, and IL-8, and induced activation of the NF-κB signaling cascade, thereby suppressing the expression of the anti-ferroptotic enzyme glutathione peroxidase 4 (GPX4). These changes resulted in excessive accumulation of reactive oxygen species, enhanced lipid peroxidation, elevated ferrous iron (Fe

Indexed as

FerroptosisHeat stressInflammationIntramuscular preadipocytesNF-κB signaling pathway

Identifiers

PMID42211753
PMCPMC13213671

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.