Evidence map›Paper›PMID 42211737›Full record

ArticleJournal of mood and anxiety disorders2026

Characterizing emotion dynamics in remitted depression: A network approach using ecological momentary assessment.

Emma H Palermo, Hadar Fisher, Jacob M Blank, Claire Anderson, Mario Bogdanov, David C Steinberger, Yinru Long, Genevieve P Nowicki, Grace W Smith, Christian A Webb and 2 more

Abstract read
In one paragraph

Article in Journal of mood and anxiety disorders, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0cells of the map it votes in
0citing papers in PubMed
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Emma H PalermoCenter for Depression, Anxiety, and Stress Research, McLean Hospital, Belmont, MA, USA.
Hadar FisherCenter for Depression, Anxiety, and Stress Research, McLean Hospital, Belmont, MA, USA.
Jacob M BlankCenter for Depression, Anxiety, and Stress Research, McLean Hospital, Belmont, MA, USA.
Claire AndersonCenter for Depression, Anxiety, and Stress Research, McLean Hospital, Belmont, MA, USA.
Mario BogdanovCenter for Depression, Anxiety, and Stress Research, McLean Hospital, Belmont, MA, USA.
David C SteinbergerCenter for Depression, Anxiety, and Stress Research, McLean Hospital, Belmont, MA, USA.
Yinru LongCenter for Depression, Anxiety, and Stress Research, McLean Hospital, Belmont, MA, USA.
Genevieve P NowickiCenter for Depression, Anxiety, and Stress Research, McLean Hospital, Belmont, MA, USA.
Grace W SmithCenter for Depression, Anxiety, and Stress Research, McLean Hospital, Belmont, MA, USA.
Christian A WebbCenter for Depression, Anxiety, and Stress Research, McLean Hospital, Belmont, MA, USA.
Manuel KuhnCenter for Depression, Anxiety, and Stress Research, McLean Hospital, Belmont, MA, USA.
Diego A PizzagalliCenter for Depression, Anxiety, and Stress Research, McLean Hospital, Belmont, MA, USA.

Funding

Project 4_Bruchas : Circuit-level Approaches for Dissecting Approach/Avoidance Behaviors Mediated by Nociceptin Systems in MiceP50MH119467 · NIMH · MCLEAN HOSPITAL · PI PIZZAGALLI, DIEGO A · 2020 to 2024
$15.9M
Neuroimaging Studies of Reward Processing in DepressionR37MH068376 · NIMH · UNIVERSITY OF CALIFORNIA-IRVINE · PI Diego A Pizzagalli · 2016 to 2026
$7.4M
NIMH NIH HHS P50 MH119467NIMH NIH HHS R37 MH068376
6 · The paper itself

Abstract

Background: Maladaptive emotion dynamics and processes, such as emotional inflexibility and dominance of negative emotions, are characteristic of depression. The extent to which these abnormalities persist following depressive episodes, and represent a vulnerability factor for recurrent depressive episodes, remains unknown. The current study investigated whether emotion dynamics predict depressive symptoms in individuals with remitted depression (rMDD) and healthy controls (HC). Methods: 98 adults (HC: n = 50; rMDD: n = 48) completed a three-week ecological momentary assessment protocol, in which they responded to two items probing positive emotions and three items probing negative emotions six times daily. Contemporaneous and temporal networks were constructed using multilevel vector autoregressive models. Density was calculated as a measure of emotional inflexibility and In- and Out-Expected Influence were calculated as measures of centrality. Linear regression models examined if density predicted clinical outcomes at the 6-month follow-up assessment. Results: Individuals with rMDD had significantly denser temporal emotional networks than HC participants. Groups also showed differential patterns of the most influential nodes in temporal and contemporaneous networks. Greater temporal density and contemporaneous density was significantly associated with increased depressive symptoms at the 6-month follow-up, assessed through both clinician-rated and self-report measures. Conclusions: Abnormalities in emotion dynamics persist following remission from depression and can be used to predict future depressive symptoms, suggesting these may represent a vulnerability factor for depression. Future research should study if interventions based on emotion networks targeting maladaptive emotional processes are able to prevent future depression.

Indexed as

Ecological Momentary AssessmentEmotion DynamicsNetwork ScienceRemitted DepressionVulnerability

Identifiers

PMID42211737
PMCPMC13214525

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.