Evidence map›Paper›PMID 42211684›Full record

ArticleCurrent opinion in physiology2025

Impact of microRNAs and long noncoding RNAs in skeletal and cardiac muscles.

Gabriela P Diniz, Joanne Chan, John D Mably, Da-Zhi Wang

Abstract read
In one paragraph

Article in Current opinion in physiology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Gabriela P DinizCenter for Regenerative Medicine, USF Health Heart Institute, University of South Florida, Tampa, FL, USA.
Joanne ChanCenter for Regenerative Medicine, USF Health Heart Institute, University of South Florida, Tampa, FL, USA.
John D MablyCenter for Regenerative Medicine, USF Health Heart Institute, University of South Florida, Tampa, FL, USA.
Da-Zhi WangCenter for Regenerative Medicine, USF Health Heart Institute, University of South Florida, Tampa, FL, USA.

Funding

Molecular Mechanisms Controlling Lymphatic Vascular Function in Health and DiseaseR01HL133216 · NHLBI · BOSTON CHILDREN'S HOSPITAL · PI CHEN, HONG, DIXON, JAMES BRANDON · 2016 to 2025
$6.7M
Targeting Endothelial Epsins to Ameliorate Myocardial IschemiaR01HL174928 · NHLBI · BOSTON CHILDREN'S HOSPITAL · PI Hong Chen, Kaifu Chen · 2024 to 2026
$2.4M
Function and Mechanism of the Intercalated Disc Protein XinB in Cardiomyocyte Proliferation and Cardiac RegenerationR01HL168900 · NHLBI · UNIVERSITY OF SOUTH FLORIDA · PI Da-Zhi Wang · 2023 to 2026
$2.2M
lncRNA Function and Mechanisms during Cardiac Development and DiseaseR01HL165794 · NHLBI · UNIVERSITY OF SOUTH FLORIDA · PI Da-Zhi Wang · 2023 to 2026
$2.2M
CDK13 function in heart development and congenital heart diseaseR01HL177546 · NHLBI · UNIVERSITY OF SOUTH FLORIDA · PI Da-Zhi Wang · 2025 to 2026
$1.4M
NHLBI NIH HHS R01 HL133216NHLBI NIH HHS R01 HL165794NHLBI NIH HHS R01 HL168900NHLBI NIH HHS R01 HL174928NHLBI NIH HHS R01 HL177546
6 · The paper itself

Abstract

Recent advances in technology have accelerated our ability to define the functions of noncoding RNA (ncRNA). Beyond their known roles in regulating molecular and cellular processes, new mechanisms and interacting partners for ncRNAs have been revealed. In this review, we focus on recent discoveries of long noncoding RNAs (lncRNAs) and microRNAs (miRNAs) in skeletal and cardiac muscles. In addition to sharing a sarcomeric organization and contractile function, both tissues also utilize similar mechanisms and genetic networks during myogenic differentiation, tissue repair, and regeneration and in disease progression. Thus, knowledge gained about the roles of these ncRNAs in cardiac and skeletal muscles may reveal shared mechanisms and functions relevant to both muscle types as well as to understanding their rules in other tissues. Ultimately, this information could be exploited to develop new diagnostic biomarkers and novel therapies for diseases affecting cardiac and skeletal muscle.

Identifiers

PMID42211684
PMCPMC13215702

What OpenQuestion holds

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LicenceCC BY-NC-ND
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.