Evidence map›Paper›PMID 42211660›Full record

ArticleFrontiers in cellular and infection microbiology2026

Lower respiratory tract microbiota characteristics in patients with

Yongchao Jiang, Rong Wang, Xin Qin, Liang Shen, Hui Xing, Fan Ye, Lijuan Yin, Yang Yang, Chunhua Wang, Tangjie Xu and 1 more

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In one paragraph

Article in Frontiers in cellular and infection microbiology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0citing papers in PubMed
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Yongchao Jiang *Department of Central Laboratory, Xiangyang Central Hospital, Affiliated Hospital of Hubei University of Arts and Science, Xiangyang, Hubei, China.
Rong Wang *Department of Central Laboratory, Xiangyang Central Hospital, Affiliated Hospital of Hubei University of Arts and Science, Xiangyang, Hubei, China.
Xin Qin *School of Basic Medicine, Hubei University of Arts and Science, Xiangyang, Hubei, China.
Liang ShenDepartment of Central Laboratory, Xiangyang Central Hospital, Affiliated Hospital of Hubei University of Arts and Science, Xiangyang, Hubei, China.
Hui XingDepartment of Central Laboratory, Xiangyang Central Hospital, Affiliated Hospital of Hubei University of Arts and Science, Xiangyang, Hubei, China.
Fan YeDepartment of Central Laboratory, Xiangyang Central Hospital, Affiliated Hospital of Hubei University of Arts and Science, Xiangyang, Hubei, China.
Lijuan YinCollege of Biotechnology, Tianjin University of Science & Technology, Tianjin, China.
Yang YangShenzhen Key Laboratory of Pathogen and Immunity, National Clinical Research Center for Infectious Disease, State Key Discipline of Infectious Disease, Shenzhen Third People's Hospital, Second Hospital Affiliated to Southern University of Science and Technology, Shenzhen, China.
Chunhua WangDepartment of Central Laboratory, Xiangyang Central Hospital, Affiliated Hospital of Hubei University of Arts and Science, Xiangyang, Hubei, China.
Tangjie XuDepartment of Central Laboratory, Xiangyang Central Hospital, Affiliated Hospital of Hubei University of Arts and Science, Xiangyang, Hubei, China.
Mengjun TangDepartment of Central Laboratory, Xiangyang Central Hospital, Affiliated Hospital of Hubei University of Arts and Science, Xiangyang, Hubei, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Introduction: Methods: Here, we performed 16S rRNA gene sequencing of bronchoalveolar lavage fluid collected from older adults with PAP at hospital admission and discharge, yielding 42 paired samples. We characterized longitudinal microbiota dynamics, identified candidate microbial biomarkers using LEfSe and random forest analyses, inferred functional profiles with Tax4Fun2, and compared microbiota-associated changes following meropenem-based therapy (n = 12) or levofloxacin-based therapy (n = 9). Results: PAP was associated with marked shifts in LRT microbial community structure, with post-treatment samples showing reduced Discussion: Collectively, these findings define the LRT microbiota landscape in elderly patients with PAP, nominate candidate microbial biomarkers, and indicate that antibiotic regimen is associated with distinct post-treatment microbial community structures, with potential implications for therapeutic decision-making.

Indexed as

Anti-Bacterial AgentsMicrobiotaPneumonia, BacterialPseudomonas aeruginosaPseudomonas InfectionsRespiratory SystemAgedAged, 80 and overBacteriaBiomarkersBronchoalveolar Lavage FluidFemaleHumansLevofloxacinMaleMeropenemAnti-Bacterial AgentsBiomarkersLevofloxacinMeropenemRNA, Ribosomal, 16Santibiotic therapyelderly patientslower respiratory tract microbiotamicrobial biomarkersPseudomonas aeruginosa pneumonia

Identifiers

PMID42211660
PMCPMC13212292

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.