ArticleCureus2026
Perioperative Prophylaxis in Pediatric Factor VII Deficiency: Experience From Rabat Children's Hospital.
Article in Cureus, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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8 authors.
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No grant is acknowledged in the PubMed record.
Abstract
backgroundFactor VII (FVII) deficiency is a rare inherited bleeding disorder characterized by heterogeneous clinical manifestations and unpredictable bleeding risk. Surgical procedures in affected children may expose them to significant perioperative bleeding, highlighting the importance of appropriate prophylactic management.
objectiveThe objective of this study is to evaluate postoperative hemostatic outcomes and hemorrhagic complications according to the type of surgery and perioperative prophylaxis in children with FVII deficiency.
methodsWe conducted a retrospective review of the medical records of patients with confirmed FVII deficiency who underwent surgical procedures. Collected data included demographic characteristics, baseline FVII activity levels, type of surgery, perioperative prophylaxis, and postoperative outcomes.
resultsEight children aged 4-6 years were included. Baseline FVII activity levels ranged from 1.6% to 22%. Surgical procedures included circumcision, hernia repair, tonsillectomy, and dental extractions. Prophylaxis consisted mainly of recombinant activated factor VII at 30 µg/kg administered 30 minutes before surgery, while one patient received fresh frozen plasma (FFP) at 20 mL/kg. Postoperative bleeding was minimal overall. Two patients developed complications: a scrotal hematoma in the patient who received FFP prophylaxis and a bleeding episode revealing previously undiagnosed FVII deficiency. No thrombotic events were observed.
conclusionsPerioperative prophylaxis with rFVIIa was associated with favorable hemostatic outcomes in children with congenital FVII deficiency undergoing surgery. A single preoperative dose appeared sufficient for minor procedures in this cohort; however, these findings should be interpreted with caution, given the small sample size (n=8), and require confirmation in larger studies.
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