ArticleFrontiers in oncology2026
Urinary DNA methylation biomarkers for bladder cancer diagnosis: a single center case-control study.
Article in Frontiers in oncology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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8 authors.
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Abstract
Background: Noninvasive detection of bladder cancer remains challenging because many urine tests trade sensitivity for specificity. We evaluated whether a biologically grounded, complementary three-gene methylation panel measured in urine could improve diagnostic performance. Methods: We conducted a single-center 1:1 matched case-control study using clinically relevant urine samples. Urine DNA was subjected to bisulfite conversion and quantitative methylation analysis targeting three gene loci ( Results: One hundred and seventy-two subjects (86 cases and 86 controls) with a mean age of 60.24 ± 12.54 and 59.70 ± 12.75 years old were included. Conclusions: A urine-based three-gene methylation panel (
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