Evidence map›Paper›PMID 42211407›Full record

ArticleInternational journal of population data science2026

E-Research Institutional Cloud Architecture (ERICA): An Orchestration Meta-Framework for Establishing Trusted Research Environments Using Public Cloud Computing.

Timothy R Churches, Richard Green, Phi Bang Nguyen, Md Shajedur Rahman Shawon, Louisa R Jorm

Abstract read
In one paragraph

Article in International journal of population data science, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Timothy R ChurchesIngham Institute for Applied Medical Research, Syndey, Australia.
Richard GreenUniversity of New South Wales, Sydney, Australia.
Phi Bang NguyenUniversity of New South Wales, Sydney, Australia.
Md Shajedur Rahman ShawonUniversity of New South Wales, Sydney, Australia.
Louisa R JormUniversity of New South Wales, Sydney, Australia.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Introduction: The E-Research Institutional Cloud Architecture (ERICA) is a code-driven orchestration framework that automates the configuration and management of Amazon Web Services (AWS) resources to provide trusted research environments (TREs) for sensitive data. Independent ERICA TREs are now operational in universities and government agencies. The framework was developed by the University of New South Wales, Australia, with support from the Australian Research Data Commons. Objectives: ERICA was designed to overcome the limitations of traditional on-premise TREs by providing secure, scalable, and flexible cloud environments that protect privacy while enabling advanced, data-intensive research. Approach: Using an infrastructure-as-code model, ERICA delivers consistent, reliable, and error-free setup of Project Spaces. It integrates robust security features, including encryption-at-rest and in transit, and multi-factor authentication. Hosted in AWS onshore data centres, ERICA ensures data sovereignty while supporting diverse operating systems and high-performance computing configurations. The architecture also allows rapid deployment of new AWS services, including generative AI tools, within research workspaces. Discussion: ERICA implements the Five Safes framework-covering safe projects, people, data, settings, and outputs-to ensure compliance and secure research. Its modular architecture enables multiple independent TREs, each governed by host-institution policies and capable of supporting hundreds of Project Spaces. This flexibility allows replication across any jurisdiction with AWS public cloud infrastructure. However, reliance on AWS introduces challenges, including charges in US dollars and delayed rollout of new services in smaller regions. Conclusions: ERICA represents a step change in providing privacy-by-design cloud infrastructure for sensitive, data-intensive research. By combining strong governance with the scalability of AWS, it enables researchers to work securely with large, complex datasets while rapidly adopting cutting-edge analytical tools. ERICA TREs offer a replicable, future-proof model for supporting secure research at scale.

Indexed as

Cloud ComputingComputer SecurityResearchAustraliaConfidentialityHumansInternetNew South Walescloud computingfive safessensitive dataTrusted Research Environment

Identifiers

PMID42211407
PMCPMC13213532

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.