ArticleBiomarker insights2026
Bacterial Fluorescence-Based Biosensor for Detecting Propionate in Culture Media for Diagnostic Applications.
Article in Biomarker insights, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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7 authors.
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Abstract
Background: Engineering bacteria for disease diagnosis and treatment is an emerging area of medical research that involves assessing short-lived molecules in complex, dynamic environments. Detecting metabolites Objective: To develop a bacterial fluorescence-based biosensor capable of detecting propionate levels at the millimolar scale in low-volume samples across different culture media and optimize its application protocol. Methods: Using Results: The fluorescence-based biosensor functioned in both Luria-Bertani and Dulbecco's modified Eagle media, producing fluorescence intensities of 3863 ± 957 arbitrary units. Validation using a portable Qubit Conclusion: This cost-effective, easy-to-use protocol provides a proof-of-concept for propionate detection in biological samples, with potential future applications in clinical diagnostics, particularly for gastrointestinal disorders in which propionate serves as a biomarker, where it could be used to monitor disease progression and therapeutic interventions.
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