Evidence map›Paper›PMID 42211338›Full record

ArticleFrontiers in veterinary science2026

Desipramine treatment disrupts phagocytic and intracellular survival of

Tran Xuan Ngoc Huy, Said Abdi Salad, Trang Thi Nguyen, Ched Nicole Turbela Aguilar, Eoin Quiatchon Lajara, Wongi Min, Hu Jang Lee, Alisha Wehdnesday Bernardo Reyes, Suk Kim

Abstract read
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In one paragraph

Article in Frontiers in veterinary science, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Tran Xuan Ngoc Huy *HUTECH Institute of Applied Sciences, HUTECH University, Ho Chi Minh City, Vietnam.
Said Abdi Salad *Institute of Animal Medicine, College of Veterinary Medicine, Gyeongsang National University, Jinju, Republic of Korea.
Trang Thi NguyenInstitute of Animal Medicine, College of Veterinary Medicine, Gyeongsang National University, Jinju, Republic of Korea.
Ched Nicole Turbela AguilarInstitute of Animal Medicine, College of Veterinary Medicine, Gyeongsang National University, Jinju, Republic of Korea.
Eoin Quiatchon LajaraInstitute of Animal Medicine, College of Veterinary Medicine, Gyeongsang National University, Jinju, Republic of Korea.
Wongi MinInstitute of Animal Medicine, College of Veterinary Medicine, Gyeongsang National University, Jinju, Republic of Korea.
Hu Jang LeeInstitute of Animal Medicine, College of Veterinary Medicine, Gyeongsang National University, Jinju, Republic of Korea.
Alisha Wehdnesday Bernardo ReyesDepartment of Veterinary Paraclinical Sciences, College of Veterinary Medicine, University of the Philippines Los Baños, College, Laguna, Philippines.
Suk KimInstitute of Animal Medicine, College of Veterinary Medicine, Gyeongsang National University, Jinju, Republic of Korea.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Introduction: Methods: The effects of DMI on B. abortus infection were evaluated using RAW 264.7 macrophages and an in vivo ICR mouse model. Bacterial growth, uptake, and intracellular survival were assessed in macrophages. Gene expression and signaling pathway analyses were performed to investigate immunomodulatory mechanisms. Infected-mice were treated with DMI, and bacterial loads in target organs, as well as immune responses, were examined. Results: DMI exhibited a direct inhibitory effect against Conclusion: Together, these findings indicate that DMI exhibits both bactericidal and immunomodulatory effects beneficial to the prevention, treatment, and control of

Indexed as

Brucella abortusdesipramineICR mouseinternalizationintracellular growthpro-inflammatory cytokinesRAW 264.7 cells

Identifiers

PMID42211338
PMCPMC13212344

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.