ArticleChemical science2026
A photochemical strategy for pyrazole to imidazole conversion.
Article in Chemical science, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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15 authors.
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Abstract
Heteroaromatic scaffolds are central to modern medicinal chemistry. Methods that can reconfigure the core heterocycle of a molecule while preserving its substitution pattern would greatly streamline analogue synthesis and bioisosteric replacement. Yet, direct heterocycle-to-heterocycle interconversions remain rare. Here we report a photochemical strategy that directly converts pyrazoles into imidazoles with broad functional-group tolerance and full retention of peripheral substitution. The reaction is effective across densely substituted and bicyclic systems and extends to pyrazolo[1,5-
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