Evidence map›Paper›PMID 42211254›Full record

ArticleJournal of arthropod-borne diseases2025

Evaluation of an Electrospun Fiber Loaded with Ozonated Oil for the Treatment of Leishmaniasis Lesions in an Experimental Model.

Daniela Patrícia Tres, Carla Diel Fabrini, Janaína Fatima da Roza Cunha, Juliana Jurumenha Barreto, Mariana Pastri, Thaís Kaori Katsumata, Gabriel Nardi Fraga, Thaís Soprani Ayala, Douglas Cardoso Dragunski, Rafael Andrade Menolli

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Article in Journal of arthropod-borne diseases, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0cells of the map it votes in
0citing papers in PubMed
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Daniela Patrícia TresLaboratory of Applied Immunology, Center of Medical and Pharmaceutical Sciences, Western Parana State University, Brazil.
Carla Diel FabriniLaboratory of Applied Immunology, Center of Medical and Pharmaceutical Sciences, Western Parana State University, Brazil.
Janaína Fatima da Roza CunhaLaboratory of Applied Immunology, Center of Medical and Pharmaceutical Sciences, Western Parana State University, Brazil.
Juliana Jurumenha BarretoLaboratory of Applied Immunology, Center of Medical and Pharmaceutical Sciences, Western Parana State University, Brazil.
Mariana PastriLaboratory of Applied Immunology, Center of Medical and Pharmaceutical Sciences, Western Parana State University, Brazil.
Thaís Kaori KatsumataLaboratory of Applied Immunology, Center of Medical and Pharmaceutical Sciences, Western Parana State University, Brazil.
Gabriel Nardi FragaCenter of Engineering and Exact Sciences, Western Parana State University, Brazil.
Thaís Soprani AyalaLaboratory of Applied Immunology, Center of Medical and Pharmaceutical Sciences, Western Parana State University, Brazil.
Douglas Cardoso DragunskiCenter of Engineering and Exact Sciences, Western Parana State University, Brazil.
Rafael Andrade MenolliLaboratory of Applied Immunology, Center of Medical and Pharmaceutical Sciences, Western Parana State University, Brazil.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Cutaneous leishmaniasis (CL) is a neglected disease whose lesions may cause severe scarring and psychosocial impact. Current treatments often face poor patient adherence due to side effects and dosing. Electrospinning enables the incorporation of low-cost, bioactive compounds. Ozonated sunflower oil has shown potential to accelerate wound healing. This study aimed to evaluate electrospun fibers containing ozonated sunflower oil combined with standard anti-Leishmania therapy in lesions caused by Methods: BALB/c mice (n=5/group) were infected with Results: All the groups exhibited lesion growth (MA 12±0.8%, MOO 24±0.4%, MNO 30±0.8 and CTRL 34±0.9%), but the MA group exhibited less growth. However, in the culture of the paws after the treatment, only in the MOO group, promastigotes did not grow, while the other groups reached titers of 1/6 (MA), 1/192 (MNO) and 1/384 (CTRL). Macroscopically, the MA and MOO groups showed complete healing of the lesion. Histologically, the MA group had a thicker epidermis (p<0.05) and the MA and MOO groups presented the lowest amount of cellular infiltration. Conclusion: Treatment of cutaneous leishmaniasis lesions in a mouse model with an electrospun fiber containing ozonated oil improved drug treatment, ameliorating lesions and could be explored as an alternative treatment for this parasitic disease.

Indexed as

BALB/cCutaneous leishmaniasisElectrospun fiberOzone therapyWound healing

Identifiers

PMID42211254
PMCPMC13213473

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.