Evidence map›Paper›PMID 42211243›Full record

ArticleBritish journal of biomedical science2026

Matrix metalloproteinase activation and TNF upregulation characterize the sclerotic phase of aortic valve disease.

Elizabeth Chan-Delgado, Claudia Lerma, Juan C Echeverría, Andrea Toledo, José M Torres-Arellano, Oscar Infante, Rafael Bojalil, Jorge E Cossío-Aranda, Nydia Ávila-Vanzzini, Luis M Amezcua-Guerra and 1 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in British journal of biomedical science, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Elizabeth Chan-DelgadoMaster's Program in Chemical-Biological Sciences, National School of Biological Sciences, National Polytechnic Institute, Mexico City, Mexico.
Claudia LermaDepartment of Molecular Biology, National Institute of Cardiology Ignacio Chávez, Mexico City, Mexico.
Juan C EcheverríaDepartment of Electrical Engineering, Metropolitan Autonomous University-Iztapalapa, Mexico City, Mexico.
Andrea ToledoDepartment of Immunology, National Institute of Cardiology Ignacio Chávez, Mexico City, Mexico.
José M Torres-ArellanoDepartment of Electromechanical Instrumentation, National Institute of Cardiology Ignacio Chávez, Mexico City, Mexico.
Oscar InfanteDepartment of Electromechanical Instrumentation, National Institute of Cardiology Ignacio Chávez, Mexico City, Mexico.
Rafael BojalilHealth Care Department, Metropolitan Autonomous University-Xochimilco, Mexico City, Mexico.
Jorge E Cossío-ArandaCardiology Outpatient Clinic, National Institute of Cardiology Ignacio Chávez, Mexico City, Mexico.
Nydia Ávila-VanzziniCardiology Outpatient Clinic, National Institute of Cardiology Ignacio Chávez, Mexico City, Mexico.
Luis M Amezcua-GuerraDepartment of Immunology, National Institute of Cardiology Ignacio Chávez, Mexico City, Mexico.
Rashidi SpringallDepartment of Immunology, National Institute of Cardiology Ignacio Chávez, Mexico City, Mexico.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Introduction: Aortic valve sclerosis (AVSc) is an active pathological process driven by extracellular matrix remodeling, consistent with a potentially reversible early stage of aortic valve disease. Methods: In this cross-sectional study of 168 participants (29, normal aortic valve [NAV]; 98, AVSc; 41, aortic stenosis [AS]), serum levels of matrix metalloproteinase (MMP)-1, -2, -3, and -9, tissue inhibitor of metalloproteinases-1 (TIMP-1), tumor necrosis factor (TNF), interleukin-6 (IL-6), and transforming growth factor-beta (TGF-β) were measured. Multivariable adjustments were performed. Results: Compared with AS, AVSc was associated with higher circulating MMP-9 levels, with MMP-9 also increased relative to NAV. TIMP-1 concentrations were reduced in AVSc compared with both AS and NAV. TNF levels were higher in AVSc than in AS, while IL-6 and TGF-β did not differ among groups. Notably, MMP-9/TIMP-1 ratio was markedly increased in AVSc. Discussion: Our findings suggest that AVSc may exhibit an active proteolytic and inflammatory profile amenable to targeted anti-inflammatory and anti-proteolytic interventions.

Indexed as

Aortic ValveAortic Valve DiseaseAortic Valve StenosisMatrix MetalloproteinasesTumor Necrosis Factor-alphaAgedCross-Sectional StudiesFemaleHumansInterleukin-6MaleMatrix Metalloproteinase 9Middle AgedSclerosisTissue Inhibitor of Metalloproteinase-1Transforming Growth Factor betaInterleukin-6Matrix Metalloproteinase 9Matrix MetalloproteinasesTIMP1 protein, humanTissue Inhibitor of Metalloproteinase-1TNF protein, humanTransforming Growth Factor betaTumor Necrosis Factor-alphaaortic valve sclerosisaortic valve stenosisextracellular matrixmetalloproteinasestumor necrosis factor

Identifiers

PMID42211243
PMCPMC13212251

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.