Evidence map›Paper›PMID 42211167›Full record

ArticleBBA advances2026

Lysosomal membrane permeabilization is involved in CYP2E1-induced apoptosis in hepatocellular carcinoma cells.

Xuan Wang, An Wang, Huanhuan He, Jiaqi Qiao, Chengyi Wang, Haiyuan Du, Xiji Shu, Binlian Sun, Xiaoqing Chen, Qiongxia Chen and 4 more

Abstract read
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In one paragraph

Article in BBA advances, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0citing papers in PubMed
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Xuan WangDepartment of Pathology and Pathophysiology, School of Medicine, Jianghan University, Wuhan 430056, China.
An WangDepartment of Pathology and Pathophysiology, School of Medicine, Jianghan University, Wuhan 430056, China.
Huanhuan HeDepartment of Pathology and Pathophysiology, School of Medicine, Jianghan University, Wuhan 430056, China.
Jiaqi QiaoDepartment of Pathology and Pathophysiology, School of Medicine, Jianghan University, Wuhan 430056, China.
Chengyi WangDepartment of Pathology and Pathophysiology, School of Medicine, Jianghan University, Wuhan 430056, China.
Haiyuan DuDepartment of Pathology and Pathophysiology, School of Medicine, Jianghan University, Wuhan 430056, China.
Xiji ShuDepartment of Pathology and Pathophysiology, School of Medicine, Jianghan University, Wuhan 430056, China.
Binlian SunCancer Institute, School of Medicine, Jianghan University, Wuhan 430056, China.
Xiaoqing ChenHubei Provincial Demonstration Center for Experimental Medicine Education, School of Medicine, Jianghan University, Wuhan 430056, China.
Qiongxia ChenDepartment of Pathology and Pathophysiology, School of Medicine, Jianghan University, Wuhan 430056, China.
Xuan HuangDepartment of Pathology and Pathophysiology, School of Medicine, Jianghan University, Wuhan 430056, China.
Shaobo HuLiver transplant center, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430022, China.
Yuchen LiuCancer Institute, School of Medicine, Jianghan University, Wuhan 430056, China.
Zhengqi FuDepartment of Pathology and Pathophysiology, School of Medicine, Jianghan University, Wuhan 430056, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

CYP2E1 expression is often negatively correlated with hepatocellular carcinoma (HCC) progression, and its overexpression induces apoptosis in HCC cells. However, the underlying mechanism of CYP2E1 in apoptosis induction remains unclear. Given the crucial role of lysosomal dysfunction through lysosomal membrane permeabilization (LMP) in promoting apoptosis, this study aimed to investigate whether and how lysosomal dysfunction and LMP contribute to CYP2E1-induced apoptosis in HCC. Here, we demonstrated that CYP2E1 overexpression induced LMP, leading to the translocation of cathepsin D and subsequent apoptosis in HCC cells. Notably, cathepsin D inhibitor attenuated CYP2E1 overexpression-induced LMP and apoptosis. In addition, through sialidase Neuraminidase 4 (NEU4), CYP2E1 overexpression resulted in the deglycosylation and degradation of lysosome-associated membrane protein 1 and 2 (LAMP1/2), contributing to LMP and apoptosis both

Indexed as

CYP2E1DeglycosylationHepatocellular carcinoma cellsLysosomal membrane permeabilization

Identifiers

PMID42211167
PMCPMC13213734

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.