ArticleiScience2026
Hardwired differences: Sexually dimorphic neural connectomes in the brain-lung axis.
Article in iScience, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Authors and funding
7 authors.
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Abstract
Sexual dimorphism in lung physiology and disease is well established; yet, the underlying central circuits remain unexplored. Using retrograde trans-synaptic tracing with pseudorabies virus from the lung combined with whole-brain mapping, we uncovered fundamental sex differences in brain-lung connectivity. Male mice exhibited anterior, cognition-associated networks clustering and hemispheric lateralization, whereas female mice displayed posterior, brainstem-predominant circuits specialized for automatic respiratory control, along with more integrated and modular network architectures. These findings reveal a hardwired neural framework for sex-specific respiratory control, with implications for understanding differential susceptibility to respiratory disease between males and females.
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