ArticleiScience2026
Aberrant prefrontal activity and arousal level correlate with action initiation and response vigor in rats.
Article in iScience, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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5 authors.
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Abstract
Orchestrating learned stimulus-response (S-R) mappings is a central function of the prefrontal cortex (PFC), as evidenced by S-R selective neuronal activity during correct task performance. During errors, the "wrong" neurons are aberrantly activated. While movement vigor has been related to basal ganglia neural activity, the neural correlates linking S-R mappings to vigor remain elusive. We trained male rats to perform a head-fixed Go/NoGo task on a treadmill, enabling the recording of PFC single-unit spiking and running speed. Aberrant activation of the "wrong" S-R mapping predicts the initiation of incorrect responses, and the vigor of those responses scales with the strength of the aberrant stimulus-evoked activity. We show that such responses occur in the context of heightened arousal, addressing a classic but under-tested hypothesis linking arousal to vigor. These findings directly relate S-R mappings to response vigor and show how arousal is co-modulated with this relationship.
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