ArticleiScience2026
Concurrent jamming and mesenchymal-to-epithelial transitions during airway basal stem cell differentiation.
Article in iScience, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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9 authors.
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Abstract
Under homeostatic conditions, the human airway epithelium remains well-differentiated, stable, and resistant to external insults. This collective transitions between a stationary and a migratory state under various circumstances, including cellular differentiation and pathological conditions such as asthma. As human airway basal stem cells differentiate and form a stable tissue, they transition from a collectively migratory, fluid-like, unjammed phase to a stationary, solid-like, jammed phase. Here, we demonstrate that jamming during basal stem cell differentiation coincides with the mesenchymal-to-epithelial transition (MET). We show that cells from patients with asthma exhibit delayed MET and jamming, both of which are accelerated by the inhibition of TGF-β receptor activity. Reciprocally, TGF-β priming of healthy cells delays both MET and jamming, mimicking the delayed transitions observed in asthmatic cells. Our data reveal a central role for both epithelial-mesenchymal and jamming transitions in the cellular plasticity and dynamics governing the differentiation of human airway basal stem cells.
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