Evidence map›Paper›PMID 42211069›Full record

ArticleMaterials today. Bio2026

A honeysuckle-decorated nanoimmunomodulator hijacks Macrophage-BMSC crosstalk to promote arthritic regeneration.

Yuan Ma, Shan He, Hanzhong Liu, Jinye Zhang, Wenguo Huang, Yuan Gu, Naiqian Cui, Jikun Qian, Mincheng Lu, Daorong Xu and 2 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Materials today. Bio, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Yuan MaDivision of Orthopaedics and Traumatology, Department of Orthopaedics, Nanfang Hospital, Southern Medical University, Guangzhou, 510515, China.
Shan HeDepartment of Burns, Nanfang Hospital, Southern Medical University, Guangzhou, 510515, China.
Hanzhong LiuDepartment of Orthopaedics, The Seventh Affiliated Hospital of Sun Yat-sen University, Shenzhen, China.
Jinye ZhangDivision of Orthopaedics and Traumatology, Department of Orthopaedics, Nanfang Hospital, Southern Medical University, Guangzhou, 510515, China.
Wenguo HuangDepartment of Burns, Nanfang Hospital, Southern Medical University, Guangzhou, 510515, China.
Yuan GuDivision of Orthopaedics and Traumatology, Department of Orthopaedics, Nanfang Hospital, Southern Medical University, Guangzhou, 510515, China.
Naiqian CuiDivision of Orthopaedics and Traumatology, Department of Orthopaedics, Nanfang Hospital, Southern Medical University, Guangzhou, 510515, China.
Jikun QianDivision of Orthopaedics and Traumatology, Department of Orthopaedics, Nanfang Hospital, Southern Medical University, Guangzhou, 510515, China.
Mincheng LuDepartment of Immunology, International Cancer Center, Shenzhen University Medical School, Shenzhen, 518055, China.
Daorong XuDivision of Orthopaedics and Traumatology, Department of Orthopaedics, Nanfang Hospital, Southern Medical University, Guangzhou, 510515, China.
Zhiqing LiDepartment of Burns, Nanfang Hospital, Southern Medical University, Guangzhou, 510515, China.
Bin YuDivision of Orthopaedics and Traumatology, Department of Orthopaedics, Nanfang Hospital, Southern Medical University, Guangzhou, 510515, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Osteoarthritis (OA) is a chronic inflammatory joint disorder characterized by persistent synovitis and progressive cartilage degradation, driven primarily by dysregulated macrophage polarization and impaired chondrogenic differentiation of bone marrow mesenchymal stem cells (BMSCs). In this study, we innovatively developed a honeysuckle flavonoid-modified ruthenium nanocluster (RuNC@HS) nanozyme that exhibits dual superoxide dismutase (SOD) and catalase (CAT)-mimicking activities, enabling efficient reactive oxygen species (ROS) scavenging and immunomodulation. In vitro and

Indexed as

BMSC-Macrophage crosstalkHMGB1/TLR4/STAT3 axisMacrophage polarizationOsteoarthritisRuthenium nanoclusters

Identifiers

PMID42211069
PMCPMC13213683

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.