ArticleFrontiers in cardiovascular medicine2026
Multi-chamber three-dimensional myocardial strain assessment by computed tomography: a comparison with speckle tracking echocardiography and association with pulmonary hypertension in severe aortic stenosis.
Article in Frontiers in cardiovascular medicine, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Background: Myocardial strain imaging is a robust tool for evaluating extra-valvular remodelling in aortic stenosis (AS). Multi-phase cardiac computed tomography (CT) angiography acquired for transcatheter aortic valve implantation (TAVI) planning enables a novel three-dimensional (3D), geometry-independent strain assessment beyond two-dimensional (2D) transthoracic echocardiography (TTE). This study evaluates the agreement and reproducibility of CT- and TTE-derived longitudinal strain and examines its association with pulmonary hypertension (PH) in significant AS. Methods: Left ventricular global longitudinal strain (LV-GLS), left atrial global longitudinal reservoir strain (LA-LS), right ventricular global longitudinal strain (RV-GLS), and RV free-wall longitudinal strain (RV-FWLS) were determined using 2D TTE and CT-based 3D motion tracking in patients with severe AS undergoing TAVI evaluation. Patients with PH were defined using guideline-directed TTE criteria for high probability PH (H-PH: Results: Agreement between CT and TTE was strong for LV-GLS (r = 0.837), RV-GLS (r = 0.853), and RV-FWLS (r = 0.780) and moderate for LA-LS (r = 0.677) (all Conclusion: TAVI CT is a promising tool for 3D longitudinal strain assessment and a valuable adjunct to TTE for quantifying extra-valvular remodelling associated with AS progression to PH. Further studies are warranted to evaluate the prognostic value of multi-chamber CT-derived 3D strain in AS.
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