Evidence map›Paper›PMID 42210990›Full record

ArticleFrontiers in cardiovascular medicine2026

Opioid overdose and cardiovascular disease-related mortality: a retrospective analysis using real-world data from the USA, 1999-2023.

Mohamed Fawzi Hemida, Alyaa Ahmed Ibrahim, Maryam Saghir, Ahmed Elshahat, Mohammad Rayyan Faisal, Moaz Elsayed Abouelmagd, Zeyad Kholeif, Krish Patel, Noha Hammad, Pakeezah Tabasum and 6 more

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Article in Frontiers in cardiovascular medicine, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0citing papers in PubMed
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors.

Mohamed Fawzi HemidaFaculty of Medicine, Alexandria University, Alexandria, Egypt.
Alyaa Ahmed IbrahimFaculty of Medicine, Alexandria University, Alexandria, Egypt.
Maryam SaghirDepartment of Medicine, Jinnah Sindh Medical University, Karachi, Pakistan.
Ahmed ElshahatFaculty of Medicine, Al-Azhar University, Cairo, Egypt.
Mohammad Rayyan FaisalDepartment of Medicine, Dow University of Health Sciences, Karachi, Pakistan.
Moaz Elsayed AbouelmagdKasr-Alainy Faculty of Medicine, Cairo University, Cairo, Egypt.
Zeyad KholeifDepartment of Internal Medicine, Baptist Hospital of SouthEast Texas, Beaumont, TX, United States.
Krish PatelDepartment of Medicine, C. U. Shah Medical College, Surendranagar, India.
Noha HammadFaculty of Medicine, Port-Said University, Port-Said, Egypt.
Pakeezah TabasumDepartment of Medicine, Peoples University of Medical and Health Sciences for Women, Nawabshah, Pakistan.
Eshal SaghirDepartment of Medicine, Dow University of Health Sciences, Karachi, Pakistan.
Mohammed Hammad Jaber AminFaculty of Medicine, Alzaiem Alazhari University, Khartoum, Sudan.
Ahmed Elmorsy MohamedFaculty of Medicine, Tanta University, Tanta, Egypt.
Khaled AliDepartment of Internal Medicine, Rosalind Franklin University of Medicine and Science, North Chicago, IL, United States.
Basel AbdelazeemDepartment of Cardiology, West Virginia University, Morgantown, WV, United States.
Mustafa Al-JarshawiNIHR Academy, National Institute for Health & Care Research, Leeds, United Kingdom.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Cardiovascular disease (CVD) is a leading cause of mortality in the U.S., a burden amplified by the ongoing opioid epidemic. This study characterized long-term trends and disparities in mortality involving both opioid overdose and CVD from 1999 to 2023. Methods: We conducted a retrospective analysis using death certificate data from the CDC WONDER multiple cause-of-death files. Data for adults aged 15 and older were analyzed using ICD-10 codes for CVD (I00-I99) and opioid overdose (T40.0, T40.1, T40.2, T40.3, T40.4). Age-adjusted mortality rates (AAMRs) per 100,000 population and crude mortality rates (CMRs) were calculated. Joinpoint regression determined the average annual percent change (AAPC). Results: A total of 112,430 deaths involving both opioid overdose and CVD were identified. The AAMR dramatically increased from 0.36 in 1999 to 4.08 in 2023 (AAPC: 10.96; 95% CI: 8.60-13.38; Conclusion: Opioid overdose and CVD-related mortality surged, disproportionately impacting men, NH Black individuals, Western regions, and non-metropolitan areas.

Indexed as

cardiovascular diseaseCDC WONDERdisparitiesepidemiologymortalityopioid overdosetrendsUnited States

Identifiers

PMID42210990
PMCPMC13212144

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