Evidence map›Paper›PMID 42210978›Full record

ArticleBrain, behavior, & immunity - health2026

Microglia depletion alleviates the disruptions in circadian rhythms and anxiety caused by bmal1 deficiency.

Song Gong, Yuxue Chen, Lihan Su, Ensheng Yao, Zhanfei Li, Xinghua Liu, Shi Li

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Brain, behavior, & immunity - health, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Song GongDivision of Trauma Surgery, Emergency Surgery & Surgical Critical, Tongji Trauma Center, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430030, China.
Yuxue ChenDepartment of Rheumatology and Immunology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430030, China.
Lihan SuDepartment of Neurology, The First Affiliated Hospital of Shihezi University, Shihezi, Xinjiang, 832008, China.
Ensheng YaoDepartment of Neurology, The First Affiliated Hospital of Shihezi University, Shihezi, Xinjiang, 832008, China.
Zhanfei LiDivision of Trauma Surgery, Emergency Surgery & Surgical Critical, Tongji Trauma Center, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430030, China.
Xinghua LiuDivision of Trauma Surgery, Emergency Surgery & Surgical Critical, Tongji Trauma Center, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430030, China.
Shi LiDepartment of Emergency, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430022, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Microglia, the intrinsic immune cells of the brain, play a crucial role in maintaining neuronal health and circadian rhythms. BMAL1 is a core transcriptional regulator of the molecular circadian clock that coordinates daily rhythms in physiology and behavior. In this study, we investigated the impact of microglial modulation on circadian disruptions and behavioral abnormalities observed in bmal-/- mice. Our results revealed disruptions in circadian rhythms and microglial activation in bmal-/- mice, characterized by altered activity patterns and increased microglia numbers. Inhibiting microglia with PLX5622 effectively ameliorated circadian disruptions and improved behavioral performance in bmal-/- mice, as observed in open field and elevated plus-maze tests. Additionally, microglia inhibition restored structural and functional abnormalities in neurons of bmal-/- mice, including dendritic spine reduction and impaired long-term potentiation (LTP). Furthermore, we observed a normalization of proinflammatory cytokine levels (IL-1β and TNF-α) upon PLX5622 treatment, indicating a potential link between microglial modulation and neuroinflammation. Our findings highlight the intricate interplay between circadian rhythms, microglia, and neuronal health, offering insights into potential therapeutic interventions for circadian-related and neuroinflammatory disorders.

Indexed as

Behavioral abnormalitiesBmalCircadian rhythmsLTPMicrogliaNeuroinflammation

Identifiers

PMID42210978
PMCPMC13214300

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.