ArticleFrontiers in medicine2026
Establishment of reference intervals for plasma IL-6, IL-8, IL-10, and IL-1β in healthy adults from Lianyungang, Jiangsu, China: a single-center flow cytometry analysis.
Article in Frontiers in medicine, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
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Who cites it
3 citing papers in PubMed.
- Evaluation of cytokine analytical performance and optimization of quality control strategies using the six sigma model: a multicenter study.Frontiers in medicine · 2026Article
- Computational Modeling of Pro-inflammatory Cytokine-Enhanced Blood Coagulation.Computational and structural biotechnology journal · 2026Article
- Bridging sepsis physiology and biosensor engineering: a clinical perspective on electrochemical cytokine sensor design.Frontiers in bioengineering and biotechnology · 2026Article
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5 authors.
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Abstract
Background: Cytokines are central regulators of both physiological and pathological immune responses. In this study, flow cytometry was used to quantify plasma interleukin-6 (IL-6), interleukin-8 (IL-8), interleukin-10 (IL-10), and interleukin-1β (IL-1β), with the aim of establishing reference intervals to support clinical interpretation, diagnosis, and treatment. Methods: Between July and November 2025, 728 healthy adults from Jiangsu Province in eastern China were enrolled as reference individuals according to predefined inclusion and exclusion criteria. Plasma IL-6, IL-8, IL-10, and IL-1β concentrations were measured by flow cytometry. Data distribution was evaluated using the Kolmogorov-Smirnov test. In accordance with the Clinical and Laboratory Standards Institute (CLSI) C28-A3 and WS/T 402-2024, nonparametric reference intervals were established using the 95th percentile. Results: Plasma IL-6, IL-8, IL-10, and IL-1β concentrations showed non-normal distributions. No significant differences were observed by sex or age (all Conclusion: To our knowledge, this is the first study to establish reference intervals for plasma IL-6, IL-8, IL-10, and IL-1β in a healthy adult population from Lianyungang, Jiangsu, eastern China. These intervals may provide a useful basis for evaluating immune status and for supporting the diagnosis and management of related clinical conditions.
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