ArticleFrontiers in medicine2026
Association between red cell distribution width and HBV viral load and liver function parameters in patients with chronic hepatitis B: a real-world data study.
Article in Frontiers in medicine, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Background: Chronic hepatitis B virus (HBV) infection remains a major global public health challenge. Identifying accessible biomarkers that reflect disease activity is crucial for clinical management. Red cell distribution width (RDW), a parameter routinely reported in complete blood counts, has garnered increasing attention for its role in chronic inflammatory conditions. Objective: To investigate the correlation between RDW and HBV viral load and liver function parameters in patients with chronic hepatitis B (CHB). Methods: A total of 120 CHB patients admitted to Hefei Third People's Hospital (Hefei Third Clinical College of Anhui Medical University) between February 2023 and May 2025 were enrolled as the CHB group, and 70 healthy individuals undergoing routine physical examination during the same period served as controls. Levels of RDW-CV, RDW-SD, HBV DNA viral load, and liver function parameters were measured and compared between groups. Correlations between RDW and these parameters were analyzed. Results: RDW-CV and RDW-SD levels were significantly higher in the CHB group compared to controls ( Conclusion: RDW is closely associated with viral load and markers of liver injury in CHB patients. These hypothesis-generating findings suggest that RDW warrants further investigation as a potential auxiliary marker for assessing disease activity.
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