ArticleFrontiers in medicine2026
Association between the Endothelial Activation and Stress Index and all-cause mortality in patients with chronic obstructive pulmonary disease.
Article in Frontiers in medicine, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Background: Endothelial Activation and Stress Index (EASIX) predicts outcome in diverse disorders; however, its independent association with short- to medium-term mortality in critically ill patients with chronic obstructive pulmonary disease (COPD) has not been examined. Methods: Data were drawn from the Medical Information Mart for Intensive Care-IV (MIMIC-IV) database and the Critical care datebase of Zigong Municipal Hospital, Sichuan, China. We identified consecutive COPD patients admitted between 2008 and 2019 in MIMIC-IV and between 2019 and 2020 in the Zigong cohort. EASIX was calculated from platelet count, creatinine, and lactate dehydrogenase measured within 24 h of ICU entry and log Results: We included 5,012 critically ill COPD patients from MIMIC-IV and 431 from the Zigong registry. In fully-adjusted models treating log Conclusion: Elevated log
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