Evidence map›Paper›PMID 42210830›Full record

ReviewACS sensors2026

Nanomaterials for In Vivo Photoacoustic Sensing: Emerging Strategies and Future Outlook.

Yong Hua, Jesse V Jokerst

Abstract readReview
In one paragraph

Review in ACS sensors, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Yong HuaAiiso Yufeng Li Family Department of Chemical and Nano Engineering, University of California San Diego, La Jolla, San Diego, California 92093, United States.
Jesse V JokerstAiiso Yufeng Li Family Department of Chemical and Nano Engineering, University of California San Diego, La Jolla, San Diego, California 92093, United States.ORCID 0000-0003-2829-6408

Funding

A Miniaturized and High-frequency Acoustic Imaging System for Oral Health and Diseases of the Head and NeckR01DE031307 · NIDCR · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI Jesse Vincent Jokerst · 2022 to 2026
$3.1M
Photoacoustic Ultrasound to Direct Therapy of Diabetic Foot UlcersR01DK141065 · NIDDK · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI JOKERST, JESSE VINCENT · 2025 to 2025
$1.2M
New Chemical Tools to Measure Cell Membrane Tension in VivoR21GM153048 · NIGMS · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI JOKERST, JESSE VINCENT · 2024 to 2025
$435k
NIDCR NIH HHS R01 DE031307NIDDK NIH HHS R01 DK141065NIGMS NIH HHS R21 GM153048
6 · The paper itself

Abstract

Photoacoustic imaging has emerged as a powerful modality for noninvasive, high-resolution visualization of deep tissues. The integration of smart nanomaterials is now extending PAI beyond structural imaging into functional and molecular sensing. In this perspective, we highlight recent advances in the design of stimuli-responsive nanomaterials tailored for in vivo applications, with emphasis on targeting strategies, operation in the NIR-II Window, and sensing specificity. We compare always-on versus activatable probes, summarize key molecular and microenvironmental targets such as pH, reactive oxygen species, metal ions, and enzymes, and discuss how these platforms report on disease progression and therapeutic response. We also outline emerging directions including NIR-II photoacoustic nanomaterials, PAI-guided theranostic probes, and translational pathways from chemistry to the clinic. Together, these innovations are positioning nanomaterial-enabled photoacoustic sensing as a cornerstone technology for precision diagnostics and image-guided therapy in clinical.

Indexed as

NanostructuresPhotoacoustic TechniquesAnimalsHumanscontrast agentsin vivo sensingmolecular diagnostics and therapeuticsnanomaterialsphotoacoustic imaging

Identifiers

PMID42210830
PMCPMC13583985

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.