Evidence map›Paper›PMID 42210785›Full record

ArticleAdvanced science (Weinheim, Baden-Wurttemberg, Germany)2026

Asymmetrically Coordinated Dual-Atom Manganese Contrast Agents Enabling High-Efficiency T1 Enhanced MRI for Precise Tumor Visualization.

Ding Yang, Qing-Yang Li, Jianli Liang, Gengyou Li, Nan Sun, Qianqian Song, Haitao Zhu, Xiaoting Li, Zechuan Li, Jiankai Dong and 4 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Advanced science (Weinheim, Baden-Wurttemberg, Germany), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Ding YangDepartment of Radiology, Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education/Beijing), Peking University Cancer Hospital and Institute, Beijing, P. R. China.
Qing-Yang LiDepartment of Radiology, Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education/Beijing), Peking University Cancer Hospital and Institute, Beijing, P. R. China.
Jianli LiangCenter of Super-Diamond and Advanced Films (COSDAF) & Department of Chemistry, City University of Hong Kong, Kowloon, Hong Kong, P. R. China.
Gengyou LiDepartment of Cardiology, Guangzhou Institute of Cardiovascular Disease, Guangdong Key Laboratory of Vascular Diseases, The Second Affiliated Hospital, Guangzhou Medical University, Guangzhou, P. R. China.
Nan SunDepartment of Radiology, Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education/Beijing), Peking University Cancer Hospital and Institute, Beijing, P. R. China.
Qianqian SongCollege of Physics and Materials Science, Tianjin Normal University, Tianjin, P. R. China.
Haitao ZhuDepartment of Radiology, Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education/Beijing), Peking University Cancer Hospital and Institute, Beijing, P. R. China.
Xiaoting LiDepartment of Radiology, Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education/Beijing), Peking University Cancer Hospital and Institute, Beijing, P. R. China.
Zechuan LiDepartment of Radiology, Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education/Beijing), Peking University Cancer Hospital and Institute, Beijing, P. R. China.
Jiankai DongDepartment of Cardiology, Guangzhou Institute of Cardiovascular Disease, Guangdong Key Laboratory of Vascular Diseases, The Second Affiliated Hospital, Guangzhou Medical University, Guangzhou, P. R. China.ORCID https://orcid.org/0000-0003-0659-9328
Weisheng GuoDepartment of Minimally Invasive Interventional Radiology, The Second Affiliated Hospital, School of Biomedical Engineering Guangzhou Medical University, Guangzhou, P. R. China.
Yafang XiaoDepartment of Cardiology, Guangzhou Institute of Cardiovascular Disease, Guangdong Key Laboratory of Vascular Diseases, The Second Affiliated Hospital, Guangzhou Medical University, Guangzhou, P. R. China.
Chun-Sing LeeCenter of Super-Diamond and Advanced Films (COSDAF) & Department of Chemistry, City University of Hong Kong, Kowloon, Hong Kong, P. R. China.
Ying-Shi SunDepartment of Radiology, Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education/Beijing), Peking University Cancer Hospital and Institute, Beijing, P. R. China.ORCID https://orcid.org/0000-0001-9424-1910

Funding

Beijing Hospitals Authority Clinical Medicine Development of Special Funding Support ZLRK202522Beijing Natural Science Foundation L242038Capital's Funds for Health Improvement and Research 2024-1-1022Chinese Academy of SciencesInnovation Academy for Precision Measurement Science and TechnologyNational Key R&D Program of China 2023YFC3402805National Natural Science Foundation of China 32301170National Natural Science Foundation of China 82271955National Natural Science Foundation of China 82471958Special Fund for Basic and Applied Basic Research of the Science and Technology Bureau of Guangzhou 2024A04J3505the Research Grants Council of Hong Kong Special Administrative Region, General Research Fund CityU11318322
6 · The paper itself

Abstract

Achieving atomically precise control over paramagnetic coordination environments is challenging because relaxivity's sixth power dependence on metal water distance demands sub-angstrom precision while also requiring rapid water exchange, two inherently competing requirements in conventional systems. Here, leveraging dual-atom coordination engineering as a rational material design strategy, we successfully synthesized a novel dual-atom manganese-based platform featuring a well-defined asymmetric Mn

Indexed as

Contrast MediaLiver NeoplasmsMagnetic Resonance ImagingManganeseAnimalsBoron CompoundsHumansBoron Compoundsboron nitrideContrast MediaManganeseasymmetric coordination geometrydual‐atom manganesehepatocyte‐specific imaginghierarchical boron nitrideMRI contrast agents

Identifiers

PMID42210785
PMCPMC13335771

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.