Article in Advanced science (Weinheim, Baden-Wurttemberg, Germany), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
2 · The registry
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
5 · Who and what money
Authors and funding
9 authors.
Yuan MengDepartment of Neurology, Chongqing Key Laboratory of Major Neurological and Mental Disorders, Neurology Key Laboratory of Chongqing Education Commission of China, Chongqing Key Laboratory of Neurology, The First Affiliated Hospital of Chongqing Medical University, Chongqing, China.ORCID https://orcid.org/0009-0003-4927-1733
Yanlin GuoDepartment of Neurology, Chongqing Key Laboratory of Major Neurological and Mental Disorders, Neurology Key Laboratory of Chongqing Education Commission of China, Chongqing Key Laboratory of Neurology, The First Affiliated Hospital of Chongqing Medical University, Chongqing, China.ORCID https://orcid.org/0009-0007-9146-3105
Liumi JiangDepartment of Neurology, Chongqing Key Laboratory of Major Neurological and Mental Disorders, Neurology Key Laboratory of Chongqing Education Commission of China, Chongqing Key Laboratory of Neurology, The First Affiliated Hospital of Chongqing Medical University, Chongqing, China.ORCID https://orcid.org/0009-0008-3073-2022
Jing LuoDepartment of Neurology, Chongqing Key Laboratory of Major Neurological and Mental Disorders, Neurology Key Laboratory of Chongqing Education Commission of China, Chongqing Key Laboratory of Neurology, The First Affiliated Hospital of Chongqing Medical University, Chongqing, China.ORCID https://orcid.org/0000-0002-4953-8325
Yan LiuDepartment of Neurology, Chongqing Key Laboratory of Major Neurological and Mental Disorders, Neurology Key Laboratory of Chongqing Education Commission of China, Chongqing Key Laboratory of Neurology, The First Affiliated Hospital of Chongqing Medical University, Chongqing, China.
Ziwei YuanDepartment of Neurology, Chongqing Key Laboratory of Major Neurological and Mental Disorders, Neurology Key Laboratory of Chongqing Education Commission of China, Chongqing Key Laboratory of Neurology, The First Affiliated Hospital of Chongqing Medical University, Chongqing, China.
Pingyang KeDepartment of Neurology, Chongqing Key Laboratory of Major Neurological and Mental Disorders, Neurology Key Laboratory of Chongqing Education Commission of China, Chongqing Key Laboratory of Neurology, The First Affiliated Hospital of Chongqing Medical University, Chongqing, China.
Ran DuanDepartment of Neurology, Chongqing Key Laboratory of Major Neurological and Mental Disorders, Neurology Key Laboratory of Chongqing Education Commission of China, Chongqing Key Laboratory of Neurology, The First Affiliated Hospital of Chongqing Medical University, Chongqing, China.ORCID https://orcid.org/0009-0008-9292-4986
Fei XiaoDepartment of Neurology, Chongqing Key Laboratory of Major Neurological and Mental Disorders, Neurology Key Laboratory of Chongqing Education Commission of China, Chongqing Key Laboratory of Neurology, The First Affiliated Hospital of Chongqing Medical University, Chongqing, China.ORCID https://orcid.org/0000-0002-5981-2922
Funding
Chongqing Chief Expert Studio program 2022Key Basic Research Project of the Discipline Climbing Plan of the First Affiliated Hospital of Chongqing Medical University cyyy-xkdfjh-jcyj-202306National Natural Science Foundation of China 82271496Natural Science Foundation of Chongqing CSTB2024NSCQ-MSX0215Young and Middle-aged Medical Excellence Team Program of Chongqing 2022
6 · The paper itself
Abstract
Metabolic reprogramming is increasingly implicated in epilepsy, yet the mechanisms linking metabolic shifts to neuronal hyperexcitability remain elusive. Here, we identify lactate-driven histone H3 lysine 18 lactylation (H3K18la), a novel post-translational modification, as a critical epigenetic regulator of seizure susceptibility. Using kainic acid (KA)-induced epilepsy models, we demonstrate that enhanced glycolytic flux through pyruvate kinase M2 (PKM2) generates excess lactate, driving robust H3K18la elevation in neurons during acute epileptogenesis. Chromatin immunoprecipitation sequencing (ChIP-seq) analysis revealed that this epigenetic mark promotes transcriptional upregulation of the E3 ubiquitin ligase Cop1. COP1 subsequently promotes K48-linked polyubiquitination and proteasomal degradation of the γ-aminobutyric acid type A (GABA
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.
Enhanced Glycolysis-Driven Histone H3K18 Lactylation Regulates Epileptogenesis by Modulating the E3 Ubiquitin Ligase COP1. · full record | OpenQuestion