Evidence map›Paper›PMID 42210780›Full record

ArticleAdvanced science (Weinheim, Baden-Wurttemberg, Germany)2026

RNA Helicase DDX21 Controls CD4

Yujuan Zhang, Chen Kan, Xinhui Yang, Yajuan Hao, Xuemin Cai, Mei Yang, Qianqian Zhang, Zhengting Wang, Ning Jiang, Lei Wang and 2 more

Abstract read
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In one paragraph

Article in Advanced science (Weinheim, Baden-Wurttemberg, Germany), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Yujuan ZhangDepartment of Geriatrics, Medical Center on Aging of Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
Chen KanSchool of Biological Science, The University of Manchester, Manchester, UK.
Xinhui YangDepartment of Gastroenterology, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
Yajuan HaoDepartment of Urology, Shanghai Tenth People's Hospital, Tongji University, Shanghai, China.
Xuemin CaiInstitute For Immunology and Pathogenesis, Chongqing Medical University, Chongqing, China.
Mei YangShanghai Jiao Tong University School of Medicine-Yale Institute For Immune Metabolism, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
Qianqian ZhangDepartment of Geriatrics, Medical Center on Aging of Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
Zhengting WangDepartment of Gastroenterology, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
Ning JiangDepartment of Pathology, The First Affiliated Hospital of Chongqing Medical University, Chongqing, China.
Lei WangDepartment of Geriatrics, Medical Center on Aging of Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
Hua-Bing LiDepartment of Geriatrics, Medical Center on Aging of Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.ORCID https://orcid.org/0000-0003-3573-6803
Jing ZhouCenter For Immune-Related Diseases At Shanghai Institute of Immunology, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.

Funding

China Postdoctoral Science Foundation 2023M742314Chongqing Municipal Finance Bureau and Chongqing Municipal Education Commission 010405000001Chongqing Municipal Science and Technology Bureau CSTB2025TIAD-STX0043Chongqing Municipal Science and Technology Bureau CSTB2025TIAD-STX0045Chongqing Municipal Science and Technology Bureau CSTB2025YCJH-KYXM0002Fundamental Research Funds for the Central UniversitiesNational Key Research and Development Program of China 2021YFA1100800National Key Research and Development Program of China 2025YFC3410100National Natural Science Foundation of China 32470945National Natural Science Foundation of China 82030042National Natural Science Foundation of China 82271756National Natural Science Foundation of China 82325024National Natural Science Foundation of China 82341017National Natural Science Foundation of China 82350112National Natural Science Foundation of China 82441048National Natural Science Foundation of China 82461160323National Natural Science Foundation of China 82541015Science and Technology Research Program of Chongqing Municipal Education Commission KJZD-M202500402Shanghai Science and Technology Commission 22QA1408100Shanghai Science and Technology Commission 25J22801300The Shanghai Youth Program of Eastern Talent Plan
6 · The paper itself

Abstract

Inflammatory bowel disease (IBD) is characterized by dysregulated T cell responses. RNA helicases, including DExD-box helicase 21 (DDX21), are pivotal in RNA metabolism, but their role in T cell-mediated pathology during IBD remains unclear. Here, we demonstrate that DDX21 expression in CD4

Indexed as

CD4-Positive T-LymphocytesCell ProliferationDEAD-box RNA HelicasesInflammatory Bowel DiseasesProtein BiosynthesisAnimalsColitisDisease Models, AnimalHumansLymphocyte ActivationMiceMice, Inbred C57BLMice, KnockoutDEAD-box RNA Helicasesinflammatory bowel diseasemRNA translationRNA helicaseT cell homeostasis

Identifiers

PMID42210780
PMCPMC13336107

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.