ArticlePhysiological reports2026
Pituitary Neurolobectomy induces sustained hypotension in male Wistar rats and normalizes blood pressure in male spontaneously hypertensive rats.
Article in Physiological reports, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors.
Funding
Abstract
Arginine vasopressin is primarily recognized as an osmoregulatory hormone; however, its contribution to vascular tone and blood pressure regulation under basal and hypertensive conditions remains debated. This study examined the effects of vasopressin deficiency induced by neurointermediate pituitary lobectomy in Wistar and spontaneously hypertensive rats, compared with sham-operated controls. Water intake, urine output, plasma vasopressin and oxytocin levels, blood pressure, and heart rate were evaluated over time. Neurointermediate pituitary lobectomy produced transient diabetes insipidus followed by the restoration of water balance, while plasma vasopressin and oxytocin levels remained markedly reduced at 3- and 90-days post-surgery (p < 0.0001 vs. Sham). This deficiency was associated with sustained hypotension in Wistar rats (~27 mmHg; p < 0.05) and normalized systolic blood pressure in spontaneously hypertensive rats (~50 mmHg; p < 0.001). Acute and chronic vasopressin and oxytocin deficiency causes transient diabetes insipidus, persistent hypotension in normotensive rats, and attenuated hypertension in spontaneously hypertensive rats with unchanged heart rate, demonstrating that vasopressin plays a key role in regulating both basal and hypertensive blood pressure.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.