Evidence map›Paper›PMID 42210722›Full record

ArticleJournal of enzyme inhibition and medicinal chemistry2026

Design, synthesis, anticancer activity, and mechanistic investigation of 4,5,6,7-tetrahydrobenzo[

Kurls E Anwer, Ramadan M Ramadan, Eman S Nossier, Najla A Altwaijry, Asmaa Saleh, Stefan Bräse, Ebtehal M Husseiny

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of enzyme inhibition and medicinal chemistry, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Kurls E AnwerChemistry Department, Faculty of Science, Ain Shams University, Cairo, Egypt.ORCID 0000-0003-3017-8806
Ramadan M RamadanChemistry Department, Faculty of Science, Ain Shams University, Cairo, Egypt.ORCID 0000-0002-9755-5410
Eman S NossierPharmaceutical Medicinal Chemistry and Drug Design Department, Faculty of Pharmacy (Girls), Al-Azhar University, Cairo, Egypt.
Najla A AltwaijryDepartment of Pharmaceutical Sciences, College of Pharmacy, Princess Nourah bint Abdulrahman University, Riyadh, Saudi Arabia.
Asmaa SalehDepartment of Pharmaceutical Sciences, College of Pharmacy, Princess Nourah bint Abdulrahman University, Riyadh, Saudi Arabia.
Stefan BräseInstitute of Biological and Chemical Systems, IBCS-FMS, Karlsruhe Institute of Technology, Karlsruhe, Germany.
Ebtehal M HusseinyPharmaceutical Organic Chemistry Department, Faculty of Pharmacy (Girls), Al-Azhar University, Cairo, Egypt.ORCID 0000-0001-6594-1766

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Utilising drug design methodologies including bioisosteric modification and substituents variation, sets of 4,5,6,7-tetrahydrobenzo[

Indexed as

Antineoplastic AgentsCyclin-Dependent Kinase 2Density Functional TheoryDrug DesignMolecular Docking SimulationProtein Kinase InhibitorsThiophenesApoptosisCell Line, TumorCell ProliferationDose-Response Relationship, DrugDrug Screening Assays, AntitumorHumansMolecular StructureStructure-Activity RelationshipAntineoplastic AgentsCDK2 protein, humanCyclin-Dependent Kinase 2Protein Kinase InhibitorsThiophenesAnticancerCDK-2DFTsynthesistetrahydrobenzo[b]thiophene

Identifiers

PMID42210722
PMCPMC13224697

What OpenQuestion holds

Textmetadata
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.