ArticleAntimicrobial agents and chemotherapy2026
Standardized numbering and alignment of the KPC family of β-lactamases.
Article in Antimicrobial agents and chemotherapy, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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Who cites it
1 citing paper in PubMed.
- Avibactam-based combinations for the treatment of multidrug resistant Gram-negative bacilli infections.Le infezioni in medicina · 2026Review
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34 authors.
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Abstract
The KPC family of serine β-lactamases comprises more than 260 members. Some variants are associated with ceftazidime-avibactam resistance in clinical isolates, often linked to substitutions and/or insertions/deletions (i.e., INDELs) in three distinct loops of the KPC sequence: (i) the 164-179 loop (i.e., the Ω loop); (ii) the 237-243 loop; and (iii) the 267-275 loop. Inconsistencies in residue numbering across published reports, however, complicate the accurate annotation of KPC variants. We retrieved 267 KPC variant sequences from the Beta-Lactamase Database (BLDB) in September 2025 and analyzed sequence differences between variants using combined nucleotide and structure-guided alignment algorithms, supported by AlphaFold3 modeling in ambiguous cases. Variants were classified into four groups to comprehensively review sequence changes across the KPC family: substitutions only (
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