Evidence map›Paper›PMID 42210667›Full record

ArticleJournal of magnetic resonance imaging : JMRI2026

Longitudinal

Laura C Saunders, Guilhem J Collier, Laurie J Smith, Ho-Fung Chan, Paul J C Hughes, Scarlett Strickland, Lotta Gustafsson, Thomas Newman, Megan Plowright, Zoë Gabriel and 32 more

Abstract readMulticenter Study
In one paragraph

Article in Journal of magnetic resonance imaging : JMRI, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Editorial for "LongitudinalJournal of magnetic resonance imaging : JMRI · 2026
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

42 authors.

Laura C SaundersThe University of Sheffield, NIHR Biomedical Research Centre, Sheffield, UK.ORCID https://orcid.org/0000-0002-1080-9861
Guilhem J CollierThe University of Sheffield, NIHR Biomedical Research Centre, Sheffield, UK.ORCID https://orcid.org/0000-0002-1874-4775
Laurie J SmithThe University of Sheffield, NIHR Biomedical Research Centre, Sheffield, UK.ORCID https://orcid.org/0000-0002-5769-423X
Ho-Fung Chan2 POLARIS, Section of Medical Imaging and Technologies, Division of Clinical, Medicine, School of Medicine and Population Health, The University of Sheffield, Sheffield, UK.ORCID https://orcid.org/0000-0002-5382-2097
Paul J C HughesThe University of Sheffield, NIHR Biomedical Research Centre, Sheffield, UK.ORCID https://orcid.org/0000-0002-7979-5840
Scarlett StricklandThe University of Sheffield, NIHR Biomedical Research Centre, Sheffield, UK.
Lotta GustafssonSheffield Teaching Hospitals NHS Foundation Trust, Sheffield, UK.
Thomas NewmanThe University of Sheffield, NIHR Biomedical Research Centre, Sheffield, UK.
Megan PlowrightSheffield Teaching Hospitals NHS Foundation Trust, Sheffield, UK.
Zoë GabrielSheffield Teaching Hospitals NHS Foundation Trust, Sheffield, UK.
Lily M PearceThe University of Sheffield, NIHR Biomedical Research Centre, Sheffield, UK.
James T GristOxford Centre for Clinical Magnetic Resonance Research, University of Oxford, Oxford, UK.
Kher Lik NgUniversity of Oxford, NIHR Biomedical Research Centre, Oxford, UK.ORCID https://orcid.org/0000-0003-4518-3085
Arthur HarrisonUniversity of Nottingham, NIHR Nottingham Biomedical Research Centre, Nottingham, UK.
Charlotte E BoltonUniversity of Nottingham, NIHR Nottingham Biomedical Research Centre, Nottingham, UK.ORCID https://orcid.org/0000-0002-9578-2249
Jody BrayThe University of Sheffield, NIHR Biomedical Research Centre, Sheffield, UK.
Helen MarshallThe University of Sheffield, NIHR Biomedical Research Centre, Sheffield, UK.ORCID https://orcid.org/0000-0002-7425-1449
Graham NorquayThe University of Sheffield, NIHR Biomedical Research Centre, Sheffield, UK.
Alberto M BiancardiThe University of Sheffield, NIHR Biomedical Research Centre, Sheffield, UK.ORCID https://orcid.org/0009-0000-2765-0773
Jimmy E BallThe University of Sheffield, NIHR Biomedical Research Centre, Sheffield, UK.ORCID https://orcid.org/0000-0003-4795-4007
Neil J StewartThe University of Sheffield, NIHR Biomedical Research Centre, Sheffield, UK.ORCID https://orcid.org/0000-0001-8358-394X
Kevin M JohnsonUniversity of Madison, Wisconsin, Madison, USA.ORCID https://orcid.org/0000-0002-8660-0853
Andrew J SwiftThe University of Sheffield, NIHR Biomedical Research Centre, Sheffield, UK.
Smitha RajaramSheffield Teaching Hospitals NHS Foundation Trust, Sheffield, UK.
John BlaikleyUniversity of Manchester, Manchester, UK.
Stefan StanelUniversity of Manchester, Manchester, UK.
Paul J ColliniThe University of Sheffield, NIHR Biomedical Research Centre, Sheffield, UK.
Gary H MillsThe University of Sheffield, NIHR Biomedical Research Centre, Sheffield, UK.ORCID https://orcid.org/0000-0002-3929-2149
Rod LawsonSheffield Teaching Hospitals NHS Foundation Trust, Sheffield, UK.
Jonathan BrookeUniversity of Nottingham, NIHR Nottingham Biomedical Research Centre, Nottingham, UK.
Amanda T GoodwinUniversity of Nottingham, NIHR Nottingham Biomedical Research Centre, Nottingham, UK.ORCID https://orcid.org/0000-0002-1488-6549
Iain D StewartNational Heart & Lung Institute, Imperial College London, London, UK.
Ling-Pei HoUniversity of Oxford, NIHR Biomedical Research Centre, Oxford, UK.
Joseph JacobSatsuma Lab, Hawkes Institute, University College London, London, UK.
Thomas MeersmannUniversity of Nottingham, NIHR Nottingham Biomedical Research Centre, Nottingham, UK.ORCID https://orcid.org/0000-0003-0243-0672
Galina E PavlovskayaUniversity of Nottingham, NIHR Nottingham Biomedical Research Centre, Nottingham, UK.ORCID https://orcid.org/0000-0003-4352-3269
Fergus GleesonUniversity of Oxford, NIHR Biomedical Research Centre, Oxford, UK.
Ian P HallUniversity of Nottingham, NIHR Nottingham Biomedical Research Centre, Nottingham, UK.
Gisli JenkinsNational Heart & Lung Institute, Imperial College London, London, UK.
Jim M WildThe University of Sheffield, NIHR Biomedical Research Centre, Sheffield, UK.ORCID https://orcid.org/0000-0002-7246-8660
A A Roger ThompsonThe University of Sheffield, NIHR Biomedical Research Centre, Sheffield, UK.ORCID https://orcid.org/0000-0002-0717-4551
UK‐ILD consortium

Funding

Insigneo InstituteMedical Research Council MR/M008894/1Medical Research Council MR/W006111/1NIHR Nottingham Biomedical Research CentreNIHR Oxford Biomedical Research CentreNIHR Sheffield Biomedical Research CentreUCLH Biomedical Research CentreWellcome TrustWellcome Trust 209553/Z/17/Z
6 · The paper itself

Abstract

backgroundIt is unclear how lung function may recover in patients with residual lung abnormalities (RLAs) following COVID-19 pneumonia. PURPOSE: To evaluate lung function trends over time in patients with RLAs following hospitalization due to COVID-19. STUDY TYPE: Prospective, multicenter longitudinal cohort study. POPULATION: Twenty-four participants hospitalized due to COVID-19 with RLAs identified on CT ≥ 3 months postdischarge (median [IQR] age 69 (15) years; 3 female) underwent at least one MRI at 6 months (n = 16), 1 year (n = 19), or 2 years (n = 14). FIELD STRENGTH/SEQUENCE: 1.5 T. Dynamic contrast enhanced (DCE) 3D spoiled gradient echo, ASSESSMENT: Pulmonary blood flow, volume, and mean transit time (MTT) were calculated from DCE MRI. The fraction of STATISTICAL TESTS: Changes in metrics with time and associations between metrics were assessed using mixed-effect linear regression. Correlations were tested using Spearman's correlation coefficient. Regional differences were assessed using a Friedman's test with a Bonferroni adjustment. p < 0.05 was considered significant.

resultsPulmonary blood flow and MTT improved significantly over time (MTT: 6 months, 15.3 (IQR, 2.0); 1 year, 15.6 (1.4); 2 years, 15.0 (5.3); pulmonary blood flow: 6 months, 75.4 (IQR, 22.0); 1 year, 83.2 (47.4); 2 years, 107.3 (51.1)). RBC:M z-score was low at all three visits (6 months, -2.85 (0.98); 1 year, -2.44 (1.34); 2 years, -2.60 (1.39)), with no improvement with time (p = 0.993). VDP and Lm DATA

conclusionImprovements in lung perfusion were measured; however, there was no corresponding enhancement in RBC:M. EVIDENCE LEVEL: Level 2. TECHNICAL EFFICACY: Stage 3.

Indexed as

COVID-19LungMagnetic Resonance ImagingAgedContrast MediaFemaleHumansLongitudinal StudiesMaleMiddle AgedProspective StudiesSARS-CoV-2Xenon IsotopesContrast Mediahyperpolarized Xe-129Xenon Isotopes129XeCOVID‐19dynamic contrast enhancedhyperpolarized gas imaging

Identifiers

PMID42210667
PMCPMC13466584

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.