Evidence map›Paper›PMID 42210653›Full record

ArticleAging cell2026

Ligand-Independent Activation of Notch1 by Cathepsin L Induces CUX1/p16

Yuwei Wu, Lili Lu, Shaoyang Yan, Zewen Du, Danli Jiang, Ting Wu, Qichao Wu, Jie Liu, Johny Ebin, Wei Sun and 4 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Aging cell, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Yuwei WuAging Institute, University of Pittsburgh, Pittsburgh, Pennsylvania, USA.
Lili LuAging Institute, University of Pittsburgh, Pittsburgh, Pennsylvania, USA.
Shaoyang YanAging Institute, University of Pittsburgh, Pittsburgh, Pennsylvania, USA.
Zewen DuAging Institute, University of Pittsburgh, Pittsburgh, Pennsylvania, USA.
Danli JiangAging Institute, University of Pittsburgh, Pittsburgh, Pennsylvania, USA.
Ting WuAging Institute, University of Pittsburgh, Pittsburgh, Pennsylvania, USA.ORCID https://orcid.org/0000-0003-1708-2869
Qichao WuAging Institute, University of Pittsburgh, Pittsburgh, Pennsylvania, USA.
Jie LiuAging Institute, University of Pittsburgh, Pittsburgh, Pennsylvania, USA.
Johny EbinCenter for Pulmonary Vascular Biology and Medicine, Pittsburgh Heart, Lung, Blood, and Vascular Medicine Institute, University of Pittsburgh School of Medicine and University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania, USA.
Wei SunCenter for Pulmonary Vascular Biology and Medicine, Pittsburgh Heart, Lung, Blood, and Vascular Medicine Institute, University of Pittsburgh School of Medicine and University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania, USA.
Partha DuttaCenter for Pulmonary Vascular Biology and Medicine, Pittsburgh Heart, Lung, Blood, and Vascular Medicine Institute, University of Pittsburgh School of Medicine and University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania, USA.
Jay Xiaojun TanAging Institute, University of Pittsburgh, Pittsburgh, Pennsylvania, USA.
Jonathan K AlderDivision of Pulmonary, Allergy, and Critical Care Medicine, Dorothy P. and Richard P. Simmons Center for Interstitial Lung Disease, University of Pittsburgh, Pittsburgh, Pennsylvania, USA.ORCID https://orcid.org/0000-0003-3741-6512
Gang LiAging Institute, University of Pittsburgh, Pittsburgh, Pennsylvania, USA.

Funding

Comprehensive functional genomic analysis of the multi-disease associated CDKN2A/B locusR01AG065229 · NIA · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI FINKEL, TOREN, LI, GANG · 2021 to 2025
$2.9M
fSNP-seq and DCP-MS as a New Approach to Study AD-associated, Non-coding Functional SNP's in a Post GWAS EraR01AG056279 · NIA · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI LI, GANG · 2017 to 2019
$1.7M
NIA NIH HHS R01 AG056279NIA NIH HHS R01AG056279NIA NIH HHS R01 AG065229NIA NIH HHS R01AG065229Pennsylvania Department of Health SAP#4100087331
6 · The paper itself

Abstract

Our post-GWAS functional analysis revealed that cathepsin L (CTSL) is an upstream regulator of CUX1, and it induces p16

Indexed as

AtherosclerosisCathepsin LCellular SenescenceCyclin-Dependent Kinase Inhibitor p16Homeodomain ProteinsReceptor, Notch1Repressor ProteinsAnimalsApolipoproteins EHumansImmunoglobulin J Recombination Signal Sequence-Binding ProteinLigandsMiceTranscription FactorsApolipoproteins ECathepsin LCUX1 protein, humanCyclin-Dependent Kinase Inhibitor p16Homeodomain ProteinsImmunoglobulin J Recombination Signal Sequence-Binding ProteinLigandsNOTCH1 protein, humanReceptor, Notch1Repressor ProteinsTranscription Factors

Identifiers

PMID42210653
PMCPMC13239849

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.