ArticleJournal of microbiology and biotechnology2026
Engineered Bacterial Nanosyringes Induce Transient and Controllable Hepatic Immune-Metabolic Responses.
Article in Journal of microbiology and biotechnology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
The photorhabdus virulence cassette (PVC), a programmable protein-delivery nanodevice derived from bacterial contractile injection systems, can be engineered to possess recognizing and targeting human cells. However, whether it impacts mammalian liver function and transcriptional networks remains largely unknown. Engineered PVCs were injected intraperitoneally into BALB/c mice. Hepatic transcriptomes were analyzed by RNA sequencing (RNA-seq) and Gene Ontology/Kyoto Encyclopedia of Genes and Genomes (GO/KEGG) clustering was applied to differentially expressed genes (DEGs) in RNA-seq analysis of the liver's transcriptomes. No acute hepatotoxicity was seen, as indicated by unchanged plasma alanine transaminase (ALT) and aspartate aminotransferase (AST). RNA-seq identified 6,471 DEGs compared with the 0 h group, early transcriptional responses in (2-4 h) group were dominated by innate immune pathways (NF-κB, TNF, and chemokine), driven by upregulation of pattern-recognition receptors (
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