ArticleCancer medicine2026
Impact of Allostatic Load on Overall Survival in Patients With Endometrial Cancer.
Article in Cancer medicine, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
1 citing paper in PubMed, 1 synthesis or guideline pooled it.
- Allostatic load in female cancer patients: a systematic review.Frontiers in endocrinology · 2026Pooled it
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Authors and funding
6 authors.
Funding
Abstract
introductionEndometrial cancer (EC) mortality is rising, with increasing rates of advanced disease and high-risk histologic subtypes. Allostatic load (AL), a biomarker of cumulative physiologic stress, has been linked to cancer-associated outcomes. We evaluated the association between baseline AL and overall survival among patients with EC.
methodsPatients diagnosed with EC at a single academic center were retrospectively identified. Baseline demographic, clinical, and laboratory values were used to calculate the primary exposure of interest, AL, based on ten physiologic biomarkers. A cohort-defined threshold classified patients as having high versus low AL. Data were analyzed using unadjusted and adjusted models and Kaplan-Meier curves.
resultsA total of 2174 patients (mean age = 63.1 years, SD = 11.2) with EC were assessed for allostatic load at baseline, 69.2% met criteria for high AL (n = 1505). The median follow up time was 49.5 months (IQR = 25.7, 76.4). High AL was associated with worse overall survival (unadjusted HR: 1.70 (95% CI, 1.28, 2.24), adjusted HR 1.58; 95% CI, 1.19, 2.11). Patients with high AL had a 52% higher rate of death compared to the low AL group. High AL was more prevalent among Black patients, those who were not married, and those without private insurance (all p < 0.001).
conclusionsElevated allostatic load was associated with worse overall survival in this cohort of patients with EC, consistent with the hypothesis that physiological stress may impact survival outcomes. These findings are hypothesis-generating and suggest that physiologic stress and social disadvantage may contribute to survival differences warranting further study.
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