ArticleJournal of translational medicine2026
Distinct associations among human milk microbiota and minerals in relation to early infant growth: a longitudinal study.
Article in Journal of translational medicine, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT02755012 (Reducing Maternal Stress Due to Infection, Malnutrition and Psychosocial Conditions of Poverty), which is not on this map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Reducing Maternal Stress Due to Infection, Malnutrition and Psychosocial Conditions of Poverty: A New Paradigm for Tackling Infant Stunting
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundCurrently there is a knowledge gap in relation to the interaction of milk components and their association with infant growth. Our aim was to analyze the associations between minerals and the milk microbiome and how they associate with infant growth in the Mam-Mayan indigenous population of Guatemala.
methodsIn this longitudinal study, a total of 114 milk samples were collected from 57 mothers during early (5-46 days) and established (4-6 months) lactation. Concentrations of 12 milk minerals were analyzed. Infant growth was assessed according to the infant growth parameters [weight-for-age (WAZ) and head circumference-for-age (HCAZ) into ≥-1 SD and <-1 SD and length-for-age (LAZ) into ≥-2 SD and <-2 SD]. The milk microbiome diversity was obtained by 16S rRNA gene amplicon sequencing of the V5-V6 region.
resultsThe milk microbiome diversity differed between infants with normal and impaired growth in weight and length during early lactation, but not in established lactation. In established lactation, milk microbiome diversity only differed between infants with normal and impaired head circumference. Some bacteria could be associated with normal growth, such as Luteococcus peritonei (for all growth parameters measured, that is WAZ, LAZ and HCAZ), Bifidobacterium longum, Lancefieldella parvula, Phascolarctobacterium, Rothia mucilaginosa, Streptococcus agalactiae and Streptococcus pneumoniae (only for the LAZ and HCAZ), Janthinobacterium lividum (only WAZ) and Lactobacillus johnsonii (only HCAZ). Similarly, C. acnes could be associated with impaired growth as it was identified in infants with impaired WAZ and LAZ. Manganese and magnesium emerged as key minerals due to their high number of correlations with the milk microbiome in both normal and impaired growth. Namely, Cutibacterium acnes was differentially abundant (DA) in the mildly underweight and stunted infants and was negatively associated with manganese. On the other hand, in non-stunted and normal head circumference infants Phascolarctobacterium and Streptococcus agalactiae were positively associated with magnesium, and Streptococcus pneumoniae was positively associated with manganese.
conclusionMilk microbial composition was associated with milk mineral concentrations, and both were associated with infant growth status.
trial registrationClinicalTrials.gov ID NCT02755012 ( http://Clinicaltrials.gov/study/NCT02755012 ). Retrospectively Registered 2016-04-26.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.