ArticleJournal of translational medicine2026
An integrated peripheral immune circuit of inflammation and dysfunction underlies drug resistance in pediatric drug-resistant epilepsy.
Article in Journal of translational medicine, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
backgroundTo systematically investigate the dynamic changes in peripheral immune cell composition and function under different clinical phenotypes, detect important immune subpopulations and regulatory networks that cause drug-resistant epilepsy (DRE), and offer new theoretical and translational insights into immune classification, early intervention, and targeted therapy in pediatric DRE.
methodsPeripheral blood mononuclear cells (PBMCs) from three DRE cases, two medication-effective cases (ME), and two healthy control cases (HC) were subjected to single-cell RNA sequencing (ScRNA-seq) analysis. The results showed variations in the proportions and gene expression profiles of immune cell types among the three groups. Differential gene trend analysis was conducted to screen signaling pathways and core genes associated with DRE. Monocytes, B cells, and T cells underwent further analysis, which identified cell subpopulations strongly related to DRE and changes in DRE-associated pathways. Finally, intercellular communication analysis was conducted.
resultsMBNL1, FOS, VPS13B, Rap1, and cAMP pathways related to DRE, as well as SKAP1, RAP1B, BRAF, and FOS genes were identified. Further in-depth analysis identified the VCAN
conclusionsThis is the first study to use scRNA-seq analysis on PBMCs from children with DRE, ME, and HC. The findings identified important genes and pathways that may be associated with DRE. It identified a VCAN
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