Evidence map›Paper›PMID 42210331›Full record

ArticleVeterinary research2026

Expression of bluetongue virus core proteins VP2 and VP7 by bovine herpesvirus-4 confers protection against virulent challenge in a mouse model.

Valentina Franceschi, Pablo Nogales-Altozano, José M Rojas, Sergio Minesso, Noemí Sevilla, Gaetano Donofrio, Verónica Martín

Abstract read
In one paragraph

Article in Veterinary research, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Valentina Franceschi *Department of Veterinary Science, University of Parma, via del Taglio 10, 43126, Parma, Italy.
Pablo Nogales-Altozano *Centro de Investigación en Sanidad Animal (CISA)-Instituto Nacional de Investigación y Tecnología Agraria y Alimentaria (INIA)-Consejo Superior de Investigaciones Científicas (CSIC), Valdeolmos, 28130, Madrid, Spain.
José M RojasCentro de Investigación en Sanidad Animal (CISA)-Instituto Nacional de Investigación y Tecnología Agraria y Alimentaria (INIA)-Consejo Superior de Investigaciones Científicas (CSIC), Valdeolmos, 28130, Madrid, Spain.
Sergio MinessoDepartment of Veterinary Science, University of Parma, via del Taglio 10, 43126, Parma, Italy.
Noemí SevillaCentro de Investigación en Sanidad Animal (CISA)-Instituto Nacional de Investigación y Tecnología Agraria y Alimentaria (INIA)-Consejo Superior de Investigaciones Científicas (CSIC), Valdeolmos, 28130, Madrid, Spain.
Gaetano Donofrio *Department of Veterinary Science, University of Parma, via del Taglio 10, 43126, Parma, Italy.
Verónica Martín *Centro de Investigación en Sanidad Animal (CISA)-Instituto Nacional de Investigación y Tecnología Agraria y Alimentaria (INIA)-Consejo Superior de Investigaciones Científicas (CSIC), Valdeolmos, 28130, Madrid, Spain. veronica.martin@inia.csic.es.

Funding

Ministerio de Ciencia, Innovación y Universidades PID2021-124872OB-100Unione Europea-Next generation EU-PRIN-2022/PNRR 2022M2HP84
6 · The paper itself

Abstract

Bluetongue virus (BTV) remains a major threat to livestock health and agricultural economies worldwide due to its multiple serotypes, vector transmission, and wide geographic distribution. Vaccination is essential for controlling BTV outbreaks; however, developing vaccines that provide broad protection while complying with the requirements of differentiating infected from vaccinated animals (DIVA) remains challenging. In this study, we evaluated the antigenicity and protective efficacy of two BTV proteins, VP2 and VP7, delivered using a bovine herpesvirus-4 (BoHV-4)-based viral vector. Groups of mice lacking interferon-α/β receptor (IFNAR

Indexed as

BluetongueBluetongue virusHerpesvirus 4, BovineViral Core ProteinsViral VaccinesAnimalsCapsid ProteinsFemaleMiceMice, Inbred C57BLCapsid ProteinsViral Core ProteinsViral VaccinesVP2 protein, Bluetongue virusVP7 protein, orbivirusbovine-herpes-based vectorBTVIFNAR−/− miceimmune responseVaccines

Identifiers

PMID42210331
PMCPMC13220488

What OpenQuestion holds

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LicenceCC BY
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.