Evidence map›Paper›PMID 42210305›Full record

ArticleBMC complementary medicine and therapies2026

Bilobalide increases SK

Katesirin Ruamyod, Patcharaporn Taokum, Neennara Wongsatan, Sompol Tapechum, Wattana B Watanapa

Abstract read
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In one paragraph

Article in BMC complementary medicine and therapies, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
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1 · What the graph read from it

What it found

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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Katesirin RuamyodSiriraj Vascular Physiology Research Center, Department of Physiology, Faculty of Medicine Siriraj Hospital, Mahidol University, 2 Wanglang Road, Bangkok, 10700, Thailand.
Patcharaporn TaokumSiriraj Vascular Physiology Research Center, Department of Physiology, Faculty of Medicine Siriraj Hospital, Mahidol University, 2 Wanglang Road, Bangkok, 10700, Thailand.
Neennara WongsatanSiriraj Vascular Physiology Research Center, Department of Physiology, Faculty of Medicine Siriraj Hospital, Mahidol University, 2 Wanglang Road, Bangkok, 10700, Thailand.
Sompol TapechumDepartment of Physiology, Faculty of Medicine Siriraj Hospital, Mahidol University, 2 Wanglang Road, Bangkok, 10700, Thailand.
Wattana B WatanapaSiriraj Vascular Physiology Research Center, Department of Physiology, Faculty of Medicine Siriraj Hospital, Mahidol University, 2 Wanglang Road, Bangkok, 10700, Thailand. wattana.wat@mahidol.ac.th.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundGinkgo biloba extract and its active component bilobalide induce endothelium-dependent vasodilation in coronary and other vascular beds. This effect is associated with increased Ca

methodsWhole-cell patch-clamp recordings were performed on cultured HCAECs. Epoxyeicosatrienoic acids (EETs) and prostacyclin were quantified with enzyme-linked immunosorbent assays; nitric oxide and hydrogen peroxide were assessed with commercial kits.

resultsBilobalide dose-dependently increased whole-cell current through activation of the small-conductance Ca

conclusionsBilobalide increases HCAEC current and induces hyperpolarization by activating SK

Indexed as

Coronary VesselsCyclopentanesEndothelial CellsFuransGinkgolidesPlant ExtractsSmall-Conductance Calcium-Activated Potassium Channels8,11,14-Eicosatrienoic AcidCells, CulturedGinkgo bilobaHumansPatch-Clamp TechniquesProtein Kinase CSignal TransductionType C Phospholipases8,11,14-Eicosatrienoic AcidbilobalideCyclopentanesFuransGinkgolidesPlant ExtractsProtein Kinase CSmall-Conductance Calcium-Activated Potassium ChannelsType C PhospholipasesBilobalideCalcium-activated potassium currentEndothelial cellsEpoxyeicosatrienoic acids (EETs)Serotonin receptor

Identifiers

PMID42210305
PMCPMC13404313

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.