Trial reportBMC cancer2026
8- versus 12-week supervised resistance training with home-based physical activity during colorectal cancer treatment: a pilot randomized dose-comparison trial.
Trial report in BMC cancer, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT07307690 (Comparison of the Effectiveness of 8-week vs 12-week Physical Exercise Programmes in Patients With Colorectal Cancer), which is not on this map. Not yet cited in PubMed.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Comparison of the Effectiveness of 8-week vs 12-week Physical Exercise Programmes in Patients With Colorectal Cancer
Who cites it
0 citing papers in PubMed.
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Authors and funding
13 authors.
Funding
Abstract
backgroundPatients with colorectal cancer (CRC) undergoing systemic therapy frequently experience functional decline, fatigue, and treatment-related symptoms. Resistance training (RT) is safe during treatment, but the minimum effective duration remains unclear.
objectiveTo compare the effects of an 8-week versus 12-week supervised RT program on chemotherapy-induced peripheral neuropathy (CIPN) and selected functional, psychosocial, behavioral, and hematological/inflammatory parameters in patients with CRC.
methodsIn this pilot randomized clinical trial, 30 adults with CRC were randomized (1:1) to 8 weeks (n = 15) or 12 weeks (n = 15) of supervised RT (2 sessions/week) plus home-based physical activity (3 days/week). The primary outcome was CIPN (EORTC QLQ-CIPN20). Secondary outcomes included handgrip strength, quality of life (EORTC QLQ-C30), anxiety/depression (HADS), physical activity, and hematological/inflammatory parameters.
resultsAll participants completed the intervention, with adherence > 90% and no adverse events. No between-group differences were observed in CIPN. Handgrip strength suggested greater adjusted gains in the 12-week group for both dominant (pFDR = 0.026) and non-dominant hand (pFDR = 0.009). Psychological outcomes showed an adjusted between-group difference for HADS total score (pFDR = 0.022). Exploratory analyses suggested a reduction in NLR after 12 weeks (p = 0.043), with no significant adjusted between-group differences. Nominal between-group differences in fatigue and gastrointestinal symptoms were observed only in unadjusted analyses.
conclusionsSupervised RT during systemic treatment in CRC appears feasible and safe. In this pilot dose-comparison trial, both programs were associated with improvements in selected outcomes, although efficacy cannot be established. A 12-week duration may be associated with additional benefits; however, findings are exploratory. Larger trials including usual-care controls are needed. REGISTRATION: The clinical trial was registered in ClinicalTrials.gov (NCT07307690) on 1 January 2026.
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