ArticleBMC immunology2026
Clinical role of miR-1271-5p in severe pediatric pneumonia and its prognostic value.
Article in BMC immunology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
backgroundAs a predominant driver of pediatric mortality, severe pediatric pneumonia (SPP) is an important complication to be solved. The miR-1271-5p is universally engaged in pulmonary infection. This study focused on miR-1271-5p for the first time and aimed to reveal its role in SPP.
methodsThe study enrolled 268 children aged 2-10 years, comprising 81 healthy individuals and 187 with pneumonia. The expression level of serum miR-1271-5p was assessed by qRT-PCR. The receiver characteristic (ROC) curve was employed to distinguish pneumonia children from healthy controls. Multivariate logistic regression analyzed factors associated with progression from mild-moderate pneumonia to SPP. Multivariate Cox regression assessed the association of miR-1271-5p expression with poor prognosis, and the Kaplan-Meier survival curve was subsequently generated based on miR-1271-5p levels.
resultsSerum miR-1271-5p levels were remarkably elevated in children with pneumonia, especially SPP. Importantly, miR-1271-5p showed high diagnostic value of SPP, with the AUC of 0.877, the sensitivity of 74.9% and specificity of 87.8%. The results of multivariate logistic analysis demonstrated that miR-1271-5p was an independent risk factor for progression to SPP. Elevated serum miR-1271-5p levels were associated with poor prognosis in children with pneumonia and possessed predictive value for patients' adverse outcomes.
conclusionElevated serum miR-1271-5p was demonstrating superior diagnostic and prognostic specificity in severe pediatric pneumonia, providing a potential biomarker.
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