ArticleBMC microbiology2026
First report and genomic characterization of an mcr-10.1-carrying Enterobacter kobei strain isolated from a domestic kitchen sink in China.
Article in BMC microbiology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
backgroundThe Enterobacter cloacae complex (ECC), a member of the genus Enterobacter within the family Enterobacteriaceae, is an important opportunistic pathogen associated with nosocomial infections. Colistin is considered a last-resort antimicrobial for multidrug-resistant Gram-negative infections; however, the emergence and dissemination of plasmid-mediated colistin resistance genes, particularly mcr variants, have raised significant public health concerns. Among these, mcr-10 has been increasingly detected in ECC isolates from diverse clinical and environmental sources, underscoring the importance of genomic surveillance to elucidate its genetic context and transmission potential.
methodsSwab samples were collected from a kitchen sink and cultured for bacterial isolation, followed by species identification using MALDI-TOF MS. Antimicrobial susceptibility was determined by the broth microdilution method, with results interpreted according to EUCAST and CLSI guidelines. Whole-genome sequencing was performed using a hybrid approach combining Illumina short-read and Oxford Nanopore long-read sequencing. Genome annotation and antimicrobial resistance gene detection were conducted using RAST and ResFinder, respectively. Multilocus sequence typing and plasmid replicon typing were performed using the MLST and PlasmidFinder tools. Comparative plasmid analysis was carried out with EasyFig and BLAST Ring Image Generator, while phylogenetic relationships were inferred using a core-genome-based phylogenetic analysis, and the resulting tree was visualized with iTOL.
resultsEnterobacter kobei JX24083 was resistant to cefazolin, cefoxitin, and fosfomycin. Consistently, the isolate harbored the resistance genes bla
conclusionThe first report of an E. kobei isolate from a domestic kitchen sink in China carrying a conserved xerC-mcr-10 plasmid backbone, yet remaining susceptible to colistin, highlights the potential for silent dissemination of mcr-10 within the Enterobacter cloacae complex (ECC) and underscores the need for continuous One Health-oriented surveillance of environmental reservoirs.
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