ArticleJournal of bioenergetics and biomembranes2026
3',4'-Dihydroxyflavonol has a positive effect on the cerebellum oxidant/antioxidant system and BDNF and transmitter levels in focal brain ischemia-reperfusion.
Article in Journal of bioenergetics and biomembranes, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Cerebral ischemia-reperfusion (I/R) occurs when blood flow is restored after a temporary interruption and may lead to brain dysfunction through oxidative stress and neurotransmitter imbalance. This study aimed to determine the effect of cerebral I/R and 1-week 3',4'-Dihydroxyflavonol (DiOHF) treatment on the antioxidant/antioxidant system and glutamate, GABA, and BDNF levels in cerebellum tissue in male rats. This study was performed on 28 Wistar-albino type male rats, which were formed as follows: 1-Control Group: No anesthesia or surgical procedure was applied to the animals in this group. 2-Sham Group: After general anesthesia was induced in the animals in this group, the carotid artery regions were opened and closed. After the application, solvent application was performed for 1 week (1 ml DiOHF vehicle). 3-Ischemia-Reperfusion Group: After general anesthesia, the carotid arteries were isolated in rats and ligated for 30 min, ischemia was induced, and then reperfusion was performed. 4-Ischemia-Reperfusion + DiOHF Group: After general anesthesia, the carotid arteries were ligated for 30 min and ischemia was performed in rats, then reperfusion was performed, and then DiOHF supplementation was performed for 1 week. After one week of treatment, the animals were sacrificed under general anaesthesia, and cerebellum tissues were taken. Malondialdehyde (MDA), glutathione peroxidase (GPx), catalase (CAT), superoxide dismutase (SOD), thioredoxin (TRx-2), glutamate, GABA, and brain-derived neurotrophic factor (BDNF) levels were evaluated in the relevant tissue. I/R increased MDA, glutamate, and GABA levels, while GPx, catalase, SOD, thioredoxin and BDNF levels were decreased. However, 1 week of 3',4'-Dihydroxyflavonol treatment corrected the changes that occurred with I/R. The study results show that 1 week of 3',4'-Dihydroxyflavonol treatment after I/R has a positive effect on cerebellum changes that occur in global brain I/R.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.