Evidence map›Paper›PMID 42209833›Full record

ArticleEuropean journal of pediatrics2026

Organ size in small infants (The OSSI Study): establishing sonographic reference intervals for abdominal organs in preterm infants.

Alexandros Rahn, Sabine Pirr, Corinna Peter, Carolin Böhne, Lara Klischke, Rieke Ringlstetter, Leonie Theis, Lars Brodowski, Bettina Bohnhorst, Doris Franke and 1 more

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Article in European journal of pediatrics, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0cells of the map it votes in
0citing papers in PubMed
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Alexandros RahnDepartment of Pediatric Pulmonology, Allergology and Neonatology, Hannover Medical School, Carl-Neuberg-Str. 1, 30625, Hannover, Germany. rahn.alexandros@mh-hannover.de.ORCID http://orcid.org/0009-0003-9227-7938
Sabine PirrDepartment of Pediatric Pulmonology, Allergology and Neonatology, Hannover Medical School, Carl-Neuberg-Str. 1, 30625, Hannover, Germany.ORCID http://orcid.org/0000-0002-3624-6251
Corinna PeterDepartment of Pediatric Pulmonology, Allergology and Neonatology, Hannover Medical School, Carl-Neuberg-Str. 1, 30625, Hannover, Germany.ORCID http://orcid.org/0009-0007-5224-6941
Carolin BöhneDepartment of Pediatric Pulmonology, Allergology and Neonatology, Hannover Medical School, Carl-Neuberg-Str. 1, 30625, Hannover, Germany.ORCID http://orcid.org/0000-0003-1879-3347
Lara KlischkeDepartment of Pediatric Pulmonology, Allergology and Neonatology, Hannover Medical School, Carl-Neuberg-Str. 1, 30625, Hannover, Germany.ORCID http://orcid.org/0009-0001-6239-2893
Rieke RinglstetterInstitut for Biometrics, Hannover Medical School, Carl-Neuberg-Str. 1, 30625, Hannover, Germany.ORCID http://orcid.org/0000-0002-9795-3216
Leonie TheisInstitut for Biometrics, Hannover Medical School, Carl-Neuberg-Str. 1, 30625, Hannover, Germany.
Lars BrodowskiDepartment of Obstetrics and Gynecology, Hannover Medical School, Carl-Neuberg-Str. 1, 30625, Hannover, Germany.
Bettina BohnhorstDepartment of Pediatric Pulmonology, Allergology and Neonatology, Hannover Medical School, Carl-Neuberg-Str. 1, 30625, Hannover, Germany.ORCID http://orcid.org/0009-0003-9113-891X
Doris FrankeDepartment of Pediatric Kidney, Liver and Metabolic Diseases, Hannover Medical School, Carl-Neuberg-Str. 1, 30625, Hannover, Germany.ORCID http://orcid.org/0000-0002-8401-9985
Thomas MüllerDepartment of Pediatric Pulmonology, Allergology and Neonatology, Hannover Medical School, Carl-Neuberg-Str. 1, 30625, Hannover, Germany.ORCID http://orcid.org/0009-0009-0762-2420

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Accurate ultrasound assessment of abdominal organ size in preterm infants is essential for evaluating growth and detecting abnormalities. However, standardized reference intervals for liver, spleen, and kidney dimensions in preterms below 40 cm body length are lacking. This study aimed to establish reference intervals for these organs. 57 eutrophic preterm infants with a body length below 40 cm (gestational age: 23

conclusionThis study provides clinically relevant ultrasound reference intervals for abdominal organs in small preterm infants. These measurements may help distinguish physiological from pathological findings and guide clinical decision-making in neonatal care. WHAT IS KNOWN: • Ultrasound is the preferred imaging modality for abdominal organ assessment in preterm infants, but standardized sonographic reference intervals for infants with a body length below 40 cm are lacking. WHAT IS NEW: • This study provides the first standardized sonographic reference intervals for liver length, splenic length, and renal volume in preterm infants below 40 cm body length, using a prospective, reproducible protocol aligned with DEGUM recommendations. • Organ size correlated most strongly with body weight, followed by body length and corrected gestational age, with renal volume showing the highest overall correlations across all parameters.

Indexed as

Infant, PrematureKidneyLiverSpleenFemaleGestational AgeHumansInfant, NewbornMaleOrgan SizeProspective StudiesReference ValuesUltrasonographyAbdominal organsNeonatal ultrasoundNormative valuesPreterm infantsReference intervals

Identifiers

PMID42209833
PMCPMC13219109

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.