Evidence map›Paper›PMID 42209832›Full record

ArticleEuropean radiology2026

Quantitative MRI of pancreatic parenchyma in intraductal papillary mucinous neoplasm: association with risk stratification based on guideline features.

Kiyoka Maeba, Akihiko Kanki, Yoshihiko Fukukura, Kazuya Yasokawa, Hidemitsu Sotozono, Akira Yamamoto, Kazunori Moriya, Yu Ueda, Tsutomu Tamada

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Article in European radiology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

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2citing papers in PubMed
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2 citing papers in PubMed.

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5 · Who and what money

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9 authors.

Kiyoka MaebaDepartment of Radiology, Kawasaki Medical School, Kurashiki City, Okayama, Japan. kiyo@med.kawasaki-m.ac.jp.ORCID http://orcid.org/0000-0003-4196-0844
Akihiko KankiDepartment of Radiology, Kawasaki Medical School, Kurashiki City, Okayama, Japan.
Yoshihiko FukukuraDepartment of Radiology, Kawasaki Medical School, Kurashiki City, Okayama, Japan.
Kazuya YasokawaDepartment of Radiology, Kawasaki Medical School, Kurashiki City, Okayama, Japan.
Hidemitsu SotozonoDepartment of Radiology, Kawasaki Medical School, Kurashiki City, Okayama, Japan.
Akira YamamotoDepartment of Radiology, Kawasaki Medical School, Kurashiki City, Okayama, Japan.
Kazunori MoriyaDepartment of Radiology, Kawasaki Medical School, Kurashiki City, Okayama, Japan.
Yu UedaPhilips Japan, Minato-Ku, Tokyo, Japan.
Tsutomu TamadaDepartment of Radiology, Kawasaki Medical School, Kurashiki City, Okayama, Japan.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectivesTo investigate the association between quantitative MRI parameters of the pancreatic parenchyma and risk stratification of intraductal papillary mucinous neoplasm (IPMN). MATERIALS AND

methodsThis study included 235 participants: 163 with IPMN and 72 with a normal pancreas. IPMN cases were stratified into IPMN without guideline-based features (n = 111) and with guideline-based features (n = 52) groups based on the 2024 International Consensus Guidelines. The MRI parameters analyzed included pancreas-to-muscle signal intensity ratios on in-phase, opposed-phase, and T2-weighted images; apparent diffusion coefficient (ADC); proton density fat fraction (PDFF); and T1 and T2* relaxation times in the pancreatic head, body, and tail. Clinical data (age, sex, body mass index (BMI), HbA1c, bilirubin, amylase, and CA19-9) were collected. Associations with IPMN risk stratification were evaluated using Spearman's rank correlation and univariate and multivariate logistic regression.

resultsIn the pancreatic head, IPMN risk stratification showed significant correlations with age (p < 0.001), BMI (p < 0.001), HbA1c (p = 0.024), ADC (p = 0.025), PDFF (p = 0.008), and T1 relaxation time (p < 0.001). In the body and tail, risk stratification correlated with age (p < 0.001), BMI (p = 0.004), and T1 relaxation time (p < 0.001). In multivariate analysis, age, BMI, and T1 relaxation time were independent predictors of IPMN in both regions. T1 relaxation time significantly distinguished patients with and without guideline-based features in both regions (p < 0.001).

conclusionT1 relaxation time is significantly associated with IPMN risk stratification and may serve as a valuable imaging biomarker. KEY POINTS: Question Pancreatic fat content and fibrosis are potential imaging biomarkers, but their relationship to IPMN risk stratification has not been clearly established. Findings T1 relaxation time was independently associated with IPMN risk stratification, and T1 relaxation time differentiated normal pancreas from that with and without guideline-based features of IPMN. Clinical relevance MRI-derived T1 relaxation time demonstrates utility in IPMN risk stratification and suggests its potential as an imaging biomarker that complements guideline-based features of IPMN.

Indexed as

Carcinoma, Pancreatic DuctalMagnetic Resonance ImagingPancreatic Intraductal NeoplasmsPancreatic NeoplasmsAdultAgedAged, 80 and overFemaleHumansMaleMiddle AgedPancreasPractice Guidelines as TopicRetrospective StudiesRisk AssessmentBiomarkersChronic pancreatitisMagnetic resonance imagingPancreasPancreatic intraductal papillary mucinous neoplasm

Identifiers

PMID42209832

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.