ReviewNaunyn-Schmiedeberg's archives of pharmacology2026
Multidisciplinary management of headache in developmental age: effects on school performance, quality of life, and therapeutic perspectives.
Review in Naunyn-Schmiedeberg's archives of pharmacology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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0 citing papers in PubMed.
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Authors and funding
2 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Primary headaches represent a major public health burden in the pediatric population, with a prevalence exceeding 60%. They significantly impair quality of life, school attendance, and family dynamics, often manifesting as a complex biopsychosocial condition. This review provides a comprehensive update on the epidemiology, clinical classification, and comorbidities of pediatric primary headaches, offering a critical analysis of current diagnostic pathways and evolving therapeutic strategies. We examined recent literature, ICHD-3 classification criteria, and international consensus guidelines (AAN/AHS), focusing on the pathophysiology, neuro-psychiatric associations, and evidence-based management of migraine and tension-type headache in developmental age. Clinical evidence highlights a significant bidirectional comorbidity between headaches and neurodevelopmental disorders (ADHD, learning disabilities) as well as mood disorders (anxiety, depression), likely mediated by shared neurotransmitter dysregulation. Diagnosis remains fundamentally clinical, relying on history taking and "red flag" exclusion to rule out secondary etiologies. Regarding management, the therapeutic paradigm has shifted towards a "bio-behavioral first" approach, following evidence of high placebo response rates in prophylaxis trials (CHAMP study). While NSAIDs and triptans remain the cornerstone of acute care, emerging anti-CGRP therapies represent a promising frontier for refractory cases. Effective management of pediatric headache requires a multidisciplinary approach. The integration of lifestyle modifications, behavioral interventions (CBT, biofeedback), and judicious pharmacotherapy is superior to single-modality treatments in reducing disability, improving global functioning, and preventing chronification.
Indexed as
Identifiers
42209735What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.