Evidence map›Paper›PMID 42209699›Full record

ArticleJournal of perinatology : official journal of the California Perinatal Association2026

Efficacy of universal genome sequencing in infant extracorporeal membrane oxygenation.

Nicholas R Carr, Makenzie L Fulmer, Jennifer Rumpel, Abhishek Makkar, Burhan Mahmood, Sarah Keene, Natalie Rintoul, K Taylor Wild, Amir Ashrafi, Semsa Gogcu and 6 more

Abstract readMulticenter Study
PubMed Publisher
In one paragraph

Article in Journal of perinatology : official journal of the California Perinatal Association, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors.

Nicholas R CarrIntermountain Health, Provo, UT, USA. Nicholas.carr@hsc.utah.edu.ORCID http://orcid.org/0000-0002-2488-2568
Makenzie L FulmerARUP Laboratories, Salt Lake City, UT, USA.
Jennifer RumpelUniversity of Arkansas for Medical Sciences, Arkansas Children's Hospital, Little Rock, AR, USA.ORCID http://orcid.org/0000-0002-5883-218X
Abhishek MakkarUniversity of Texas Southwestern Medical Center, Dallas, TX, USA.ORCID http://orcid.org/0000-0003-4654-0566
Burhan MahmoodUPMC Children's Hospital of Pittsburgh, Pittsburgh, PA, USA.ORCID http://orcid.org/0000-0002-6585-992X
Sarah KeeneEmory University, Children's Healthcare of Atlanta, Atlanta, GA, USA.
Natalie RintoulChildren's Hospital of Philadelphia, Philadelphia, PA, USA.
K Taylor WildChildren's Hospital of Philadelphia, Philadelphia, PA, USA.ORCID http://orcid.org/0000-0002-0016-078X
Amir AshrafiChildren's Hospital of Orange County, Los Angeles, CA, USA.
Semsa GogcuWomen and Infants Hospital, Providence, RI and Atrium Health Wake Forest Baptist Medical Center, Winston-Salem, NC, USA.ORCID http://orcid.org/0000-0002-0429-9404
Carrie RauUniversity of Utah, Salt Lake City, UT, USA.
David PattisonARUP Laboratories, Salt Lake City, UT, USA.
Hunter BestARUP Laboratories, Salt Lake City, UT, USA.
Steven E BoydenUtah Center for Genetic Discovery, Salt Lake City, UT, USA.
Rong MaoARUP Laboratories, Salt Lake City, UT, USA.
Luca BrunelliUniversity of Utah, Salt Lake City, UT, USA.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveTo evaluate the feasibility and diagnostic yield of universal genome sequencing (GS) in infants receiving extracorporeal membrane oxygenation (ECMO). STUDY

designProspective multicenter study across eight Children's Hospital Neonatal Consortium sites (October 2021-August 2023). Infants initiated on ECMO were enrolled for GS regardless of suspected genetic disease. Demographics, ECMO indications, and results from standard-care testing and study-based GS were analyzed.

resultsTwenty-five infants were enrolled. Primary ECMO indications included congenital diaphragmatic hernia (28%), meconium aspiration syndrome (24%), and primary respiratory failure (20%). GS identified pathogenic or likely pathogenic variants in 6/25 infants (24%), including three cytogenetic-confirmed diagnoses and three molecular diagnoses identified only by GS. Variants of uncertain significance were identified in 44% of infants, while 32% had negative results.

conclusionUniversal GS during ECMO is feasible and yields a relatively high rate of clinically relevant diagnoses, supporting further assessment of the integration of genomic testing into ECMO care pathways.

Indexed as

Extracorporeal Membrane OxygenationMeconium Aspiration SyndromeRespiratory InsufficiencyWhole Genome SequencingFeasibility StudiesFemaleHernias, Diaphragmatic, CongenitalHumansInfantInfant, NewbornMaleProspective Studies

Identifiers

PMID42209699

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.